TY - JOUR
T1 - Neural circuits underlying the pathophysiology of mood disorders
AU - Price, Joseph L.
AU - Drevets, Wayne C.
N1 - Funding Information:
J.L.P. is supported by grant R01 MH070941 from the USPHS/NIMH and W.C.D. by funds from The William K. Warren Foundation.
PY - 2012/1
Y1 - 2012/1
N2 - Although mood disorders constitute leading causes of disability, until recently little was known about their pathogenesis. The delineation of anatomical networks that support emotional behavior (mainly derived from animal studies) and the development of neuroimaging technologies that allow in vivo characterization of anatomy, physiology, and neurochemistry in human subjects with mood disorders have enabled significant advances towards elucidating the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD). In this review, we integrate insights from human and animal studies, which collectively suggest that MDD and BD involve dysfunction within an extended network including the medial prefrontal cortex and anatomically-related limbic, striatal, thalamic and basal forebrain structures.
AB - Although mood disorders constitute leading causes of disability, until recently little was known about their pathogenesis. The delineation of anatomical networks that support emotional behavior (mainly derived from animal studies) and the development of neuroimaging technologies that allow in vivo characterization of anatomy, physiology, and neurochemistry in human subjects with mood disorders have enabled significant advances towards elucidating the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD). In this review, we integrate insights from human and animal studies, which collectively suggest that MDD and BD involve dysfunction within an extended network including the medial prefrontal cortex and anatomically-related limbic, striatal, thalamic and basal forebrain structures.
UR - http://www.scopus.com/inward/record.url?scp=84855312099&partnerID=8YFLogxK
U2 - 10.1016/j.tics.2011.12.011
DO - 10.1016/j.tics.2011.12.011
M3 - Review article
C2 - 22197477
AN - SCOPUS:84855312099
VL - 16
SP - 61
EP - 71
JO - Trends in Cognitive Sciences
JF - Trends in Cognitive Sciences
SN - 1364-6613
IS - 1
ER -