Network assisted analysis of De novo variants using protein-protein interaction information identified 46 candidate genes for congenital heart disease

Keyphrases

• Protein-protein Interaction 100%
• Congenital Heart Disease 100%
• Interaction Information 100%
• Assisted Analysis 100%
• Network-assisted 100%
• Risk Genes 80%
• Whole Exome Sequencing 20%
• Statistical Methods 20%
• Identify Risk 20%
• Deleterious Effects 20%
• Statistical Power 20%
• Family Study 20%
• Protein-protein Interaction Network 20%
• Disease Association 20%
• Protein-protein Interaction Data 20%
• Early Disease 20%
• Publicly Available 20%
• Sequencing Studies 20%
• Disease Genes 20%
• Developing Heart 20%
• Additional Power 20%
• Markov Random Field Model 20%
• Protein Functionality 20%
• Highly Expressed Gene 20%

Biochemistry, Genetics and Molecular Biology

• Protein-Protein Interaction 100%
• Candidate Gene 100%
• Exome Sequencing 50%
• Cohort Study 50%
• Case-Control Study 50%
• Protein-Protein Interaction Networks 50%