TY - JOUR
T1 - Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB
AU - Ginty, David D.
AU - Bonni, Azad
AU - Greenberg, Michael E.
N1 - Funding Information:
We thank Amgen for providing BDNF and NT-3, Michael Gilman for fosCAT plasmids, John Blenis for antibodies to ppsoRBn and pp708”, Simon Halegoua and Laura Rosen for GSrasDN8 cells, and Ben Neel as well as members of the Greenberg laboratory for critical reading of the manuscript. This work was supported by the Massachusetts Affiliate of the American Heart Association (grant 13-t48-912) (D. D. G.), a Medical Research Council of Canada fellowship (A. B.), the National Institutes of Health ROI grant CA43855 (M. E. G.), an American Cancer Society Faculty Research Award (FFtA-379) (M. E.G.), and a Scholar’s Award from the McKnight Endowment Fund for Neuroscience (M. E. G.).
PY - 1994/6/3
Y1 - 1994/6/3
N2 - A mechanism by which the nerve growth factor (NGF) signal is transduced to the nucleus to induce gene expression has been characterized. An NGF-inducible, Ras-dependent protein kinase has been identified that catalyzes the phosphorylation of the cyclic AMP response element-binding protein (CREB) at Ser-133. Phosphorylation of Ser-133 stimulates the ability of CREB to activate transcription in NGF-treated cells. These findings suggest that CREB has a more widespread function than previously believed and functions in the nucleus as a general mediator of growth factor responses.
AB - A mechanism by which the nerve growth factor (NGF) signal is transduced to the nucleus to induce gene expression has been characterized. An NGF-inducible, Ras-dependent protein kinase has been identified that catalyzes the phosphorylation of the cyclic AMP response element-binding protein (CREB) at Ser-133. Phosphorylation of Ser-133 stimulates the ability of CREB to activate transcription in NGF-treated cells. These findings suggest that CREB has a more widespread function than previously believed and functions in the nucleus as a general mediator of growth factor responses.
UR - http://www.scopus.com/inward/record.url?scp=0028338460&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(94)90055-8
DO - 10.1016/0092-8674(94)90055-8
M3 - Article
C2 - 8205620
AN - SCOPUS:0028338460
SN - 0092-8674
VL - 77
SP - 713
EP - 725
JO - Cell
JF - Cell
IS - 5
ER -