TY - JOUR
T1 - Nerve allotransplantation as it pertains to composite tissue transplantation
AU - Moore, Amy M.
AU - Ray, Wilson Z.
AU - Chenard, Kristofer E.
AU - Tung, Thomas
AU - Mackinnon, Susan E.
PY - 2009
Y1 - 2009
N2 - Nerve allografts provide a temporary scaffold for host nerve regeneration and allow for the repair of significant segmental nerve injuries. From rodent, large animal, and nonhuman primate studies, as well as clinical experience, nerve allografts, with the use of immunosuppression, have the capacity to provide equal regeneration and function to that of an autograft. In contrast to solid organ transplantation and composite tissue transfers, nerve allograft transplantation requires only temporary immunosuppression. Furthermore, nerve allograft rejection is difficult to assess, as the nerves are surgically buried and are without an immediate functional endpoint to monitor. In this article, we review what we know about peripheral nerve allograft transplantation from three decades of experience and apply our current understanding of nerve regeneration to the emerging field of composite tissue transplantation.
AB - Nerve allografts provide a temporary scaffold for host nerve regeneration and allow for the repair of significant segmental nerve injuries. From rodent, large animal, and nonhuman primate studies, as well as clinical experience, nerve allografts, with the use of immunosuppression, have the capacity to provide equal regeneration and function to that of an autograft. In contrast to solid organ transplantation and composite tissue transfers, nerve allograft transplantation requires only temporary immunosuppression. Furthermore, nerve allograft rejection is difficult to assess, as the nerves are surgically buried and are without an immediate functional endpoint to monitor. In this article, we review what we know about peripheral nerve allograft transplantation from three decades of experience and apply our current understanding of nerve regeneration to the emerging field of composite tissue transplantation.
KW - Composite tissue transplantation
KW - Immunosuppression
KW - Nerve allotransplantation
UR - http://www.scopus.com/inward/record.url?scp=68949111692&partnerID=8YFLogxK
U2 - 10.1007/s11552-009-9183-x
DO - 10.1007/s11552-009-9183-x
M3 - Article
C2 - 19306048
AN - SCOPUS:68949111692
VL - 4
SP - 239
EP - 244
JO - Hand
JF - Hand
SN - 1558-9447
IS - 3
ER -