Nerve allograft response: A quantitative immunological study

S. Mackinnon; A. Hudson; R. Falk; J. Bilbao; D. Kline; D. Hunter

doi:10.1227/00006123-198201000-00011

Nerve allograft response: A quantitative immunological study

S. Mackinnon, A. Hudson, R. Falk, J. Bilbao, D. Kline, D. Hunter

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Abstract

The nerve allograft response between closely and distantly related inbred strains of rats was investigated. Lewis rats (RT1¹) and Fischer rats (RT1¹) have only minor histocompatibility differences, whereas Buffalo rats (RT1(b)) and ACI rats (RT1(a)) differ from Lewis rats at the major histocompatibility locus. Lewis rats served as the recipient animals; the other three strains of rats provided donor nerves. The ⁵¹Cr release cytotoxicity assay was used to assess antigen recognition. The results showed sensitization with ACI and Buffalo nerves as early as Day 8. When the donor and recipient were matched (Lewis/Fischer), sensitization occurred very late (Day 80). By contrast, with skin allografts, sensitization occurred early with all strains (Day 10), even when the animals differed only at the minor histocompatibility loci. Histological changes were similar in all three donor strains (Fischer, Buffalo, ACI). The strain of origin of the nerve could not be deduced by an unbiased examiner.

Original language	English
Pages (from-to)	61-69
Number of pages	9
Journal	Unknown Journal
Volume	10
Issue number	1
DOIs	https://doi.org/10.1227/00006123-198201000-00011
State	Published - 1982

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title = "Nerve allograft response: A quantitative immunological study",

abstract = "The nerve allograft response between closely and distantly related inbred strains of rats was investigated. Lewis rats (RT11) and Fischer rats (RT11) have only minor histocompatibility differences, whereas Buffalo rats (RT1(b)) and ACI rats (RT1(a)) differ from Lewis rats at the major histocompatibility locus. Lewis rats served as the recipient animals; the other three strains of rats provided donor nerves. The 51Cr release cytotoxicity assay was used to assess antigen recognition. The results showed sensitization with ACI and Buffalo nerves as early as Day 8. When the donor and recipient were matched (Lewis/Fischer), sensitization occurred very late (Day 80). By contrast, with skin allografts, sensitization occurred early with all strains (Day 10), even when the animals differed only at the minor histocompatibility loci. Histological changes were similar in all three donor strains (Fischer, Buffalo, ACI). The strain of origin of the nerve could not be deduced by an unbiased examiner.",

author = "S. Mackinnon and A. Hudson and R. Falk and J. Bilbao and D. Kline and D. Hunter",

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TY - JOUR

T1 - Nerve allograft response

T2 - A quantitative immunological study

AU - Mackinnon, S.

AU - Hudson, A.

AU - Falk, R.

AU - Bilbao, J.

AU - Kline, D.

AU - Hunter, D.

PY - 1982

Y1 - 1982

N2 - The nerve allograft response between closely and distantly related inbred strains of rats was investigated. Lewis rats (RT11) and Fischer rats (RT11) have only minor histocompatibility differences, whereas Buffalo rats (RT1(b)) and ACI rats (RT1(a)) differ from Lewis rats at the major histocompatibility locus. Lewis rats served as the recipient animals; the other three strains of rats provided donor nerves. The 51Cr release cytotoxicity assay was used to assess antigen recognition. The results showed sensitization with ACI and Buffalo nerves as early as Day 8. When the donor and recipient were matched (Lewis/Fischer), sensitization occurred very late (Day 80). By contrast, with skin allografts, sensitization occurred early with all strains (Day 10), even when the animals differed only at the minor histocompatibility loci. Histological changes were similar in all three donor strains (Fischer, Buffalo, ACI). The strain of origin of the nerve could not be deduced by an unbiased examiner.

AB - The nerve allograft response between closely and distantly related inbred strains of rats was investigated. Lewis rats (RT11) and Fischer rats (RT11) have only minor histocompatibility differences, whereas Buffalo rats (RT1(b)) and ACI rats (RT1(a)) differ from Lewis rats at the major histocompatibility locus. Lewis rats served as the recipient animals; the other three strains of rats provided donor nerves. The 51Cr release cytotoxicity assay was used to assess antigen recognition. The results showed sensitization with ACI and Buffalo nerves as early as Day 8. When the donor and recipient were matched (Lewis/Fischer), sensitization occurred very late (Day 80). By contrast, with skin allografts, sensitization occurred early with all strains (Day 10), even when the animals differed only at the minor histocompatibility loci. Histological changes were similar in all three donor strains (Fischer, Buffalo, ACI). The strain of origin of the nerve could not be deduced by an unbiased examiner.

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Nerve allograft response: A quantitative immunological study

Abstract

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