TY - JOUR
T1 - Nephrotic range proteinuria associated with focal segmental glomerulosclerosis reversed with pioglitazone therapy in a patient with Dunnigan type lipodystrophy
AU - Sharma, Anjul
AU - Bourey, Raymond E.
AU - Edwards, John C.
AU - Brink, David S.
AU - Albert, Stewart G.
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/2
Y1 - 2021/2
N2 - Familial partial lipodystrophy (FPLD) is a rare disorder associated with severe insulin resistance, hypertriglyceridemia, low serum HDL cholesterol and proteinuric renal disease. Although proteinuric renal disease is not common among in patients with partial lipodystrophy, we report a patient with Dunnigan type FPLD complicated by nephrotic syndrome which resolved following treatment with the PPARγ agonist pioglitazone, CPAP, diet, and exercise.
AB - Familial partial lipodystrophy (FPLD) is a rare disorder associated with severe insulin resistance, hypertriglyceridemia, low serum HDL cholesterol and proteinuric renal disease. Although proteinuric renal disease is not common among in patients with partial lipodystrophy, we report a patient with Dunnigan type FPLD complicated by nephrotic syndrome which resolved following treatment with the PPARγ agonist pioglitazone, CPAP, diet, and exercise.
KW - Diabetes mellitus
KW - Diabetic proteinuria
KW - Focal segmental glomerulosclerosis
KW - Lipodystrophy syndrome
KW - Pioglitazone
UR - http://www.scopus.com/inward/record.url?scp=85099407473&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2020.108620
DO - 10.1016/j.diabres.2020.108620
M3 - Article
C2 - 33316307
AN - SCOPUS:85099407473
SN - 0168-8227
VL - 172
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
M1 - 108620
ER -