Nephron number and its determinants: a 2020 update

Jennifer R. Charlton, Edwin J. Baldelomar, Dylan M. Hyatt, Kevin M. Bennett

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Studies of human nephron number have been conducted for well over a century and have uncovered a large variability in nephron number. However, the mechanisms influencing nephron endowment and loss, along with the etiology for the wide range among individuals are largely unknown. Advances in imaging technology have allowed investigators to revisit the principles of renal structure and physiology and their roles in the progression of kidney disease. Here, we will review the latest data on the influences impacting nephron number, innovations made over the last 6 years to understand and integrate renal structure and function, and new developments in the tools used to count nephrons in vivo.

Original languageEnglish
Pages (from-to)797-807
Number of pages11
JournalPediatric Nephrology
Issue number4
StatePublished - Apr 2021


  • Glomerular number
  • Nephrogenesis
  • Nephron endowment


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