TY - JOUR
T1 - Nephritic Factor
T2 - Its Structure and Function and Its Relationship to Initiating Factor of the Alternative Pathway
AU - SCHREIBER, R. D.
AU - GÖTZE, O.
AU - MÜLLER‐EBERHARD, H. J.
PY - 1976/6
Y1 - 1976/6
N2 - Nephritic factor (NF) has a molecular weight of 170,000 and is composed of two disulfide‐linked 85,000‐dalton chains. NF assembles the fluid‐phase C3 convertase from Factors B and D, C3, and magnesium by physically incorporating itself into the enzyme complex. NF exerts its stabilizing effect on the cell‐bound C3/C5 convertase, EC, by physically associating itself with this complex. On decay of the cell‐bound enzyme NF is released into the fluid phase and retains its binding and stabilizing potential. Its activity is resistant to diisopropylfluorophosphate treatment. Because NF causes agglutination of EC, it must be endowed with more than one binding site.
AB - Nephritic factor (NF) has a molecular weight of 170,000 and is composed of two disulfide‐linked 85,000‐dalton chains. NF assembles the fluid‐phase C3 convertase from Factors B and D, C3, and magnesium by physically incorporating itself into the enzyme complex. NF exerts its stabilizing effect on the cell‐bound C3/C5 convertase, EC, by physically associating itself with this complex. On decay of the cell‐bound enzyme NF is released into the fluid phase and retains its binding and stabilizing potential. Its activity is resistant to diisopropylfluorophosphate treatment. Because NF causes agglutination of EC, it must be endowed with more than one binding site.
UR - http://www.scopus.com/inward/record.url?scp=0017201602&partnerID=8YFLogxK
U2 - 10.1111/j.1365-3083.1976.tb03020.x
DO - 10.1111/j.1365-3083.1976.tb03020.x
M3 - Article
C2 - 62386
AN - SCOPUS:0017201602
SN - 0300-9475
VL - 5
SP - 705
EP - 713
JO - Scandinavian Journal of Immunology
JF - Scandinavian Journal of Immunology
IS - 6-7
ER -