Neonatal NIRS monitoring: recommendations for data capture and review of analytics

Zachary A. Vesoulis, Jonathan P. Mintzer, Valerie Y. Chock

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Abstract: Brain injury is one of the most consequential problems facing neonates, with many preterm and term infants at risk for cerebral hypoxia and ischemia. To develop effective neuroprotective strategies, the mechanistic basis for brain injury must be understood. The fragile state of neonates presents unique research challenges; invasive measures of cerebral blood flow and oxygenation assessment exceed tolerable risk profiles. Near-infrared spectroscopy (NIRS) can safely and non-invasively estimate cerebral oxygenation, a correlate of cerebral perfusion, offering insight into brain injury-related mechanisms. Unfortunately, lack of standardization in device application, recording methods, and error/artifact correction have left the field fractured. In this article, we provide a framework for neonatal NIRS research. Our goal is to provide a rational basis for NIRS data capture and processing that may result in better comparability between studies. It is also intended to serve as a primer for new NIRS researchers and assist with investigation initiation.

Original languageEnglish
Pages (from-to)675-688
Number of pages14
JournalJournal of Perinatology
Volume41
Issue number4
DOIs
StatePublished - Apr 2021

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