@article{e8fd7e18c6ad450c87663d704dd6fd46,
title = "Neonatal motor functional connectivity and motor outcomes at age two years in very preterm children with and without high-grade brain injury",
abstract = "Preterm-born children have high rates of motor impairments, but mechanisms for early identification remain limited. We hypothesized that neonatal motor system functional connectivity (FC) would relate to motor outcomes at age two years; currently, this relationship is not yet well-described in very preterm (VPT; born <32 weeks{\textquoteright} gestation) infants with and without brain injury. We recruited 107 VPT infants – including 55 with brain injury (grade III–IV intraventricular hemorrhage, cystic periventricular leukomalacia, post-hemorrhagic hydrocephalus) – and collected FC data at/near term-equivalent age (35–45 weeks postmenstrual age). Correlation coefficients were used to calculate the FC between bilateral motor and visual cortices and thalami. At two years corrected-age, motor outcomes were assessed with the Bayley Scales of Infant and Toddler Development, 3rd edition. Multiple imputation was used to estimate missing data, and regression models related FC measures to motor outcomes. Within the brain-injured group only, interhemispheric motor cortex FC was positively related to gross motor outcomes. Thalamocortical and visual FC were not related to motor scores. This suggests neonatal alterations in motor system FC may provide prognostic information about impairments in children with brain injury.",
keywords = "Brain injury, Cerebral palsy, Functional connectivity, Motor cortex, Preterm birth",
author = "Cyr, {Peppar E.P.} and Lean, {Rachel E.} and Kenley, {Jeanette K.} and Sydney Kaplan and Meyer, {Dominique E.} and Neil, {Jeffery J.} and Dimitrios Alexopoulos and Brady, {Rebecca G.} and Shimony, {Joshua S.} and Rodebaugh, {Thomas L.} and Rogers, {Cynthia E.} and Smyser, {Christopher D.}",
note = "Funding Information: This work was supported by the National Institutes of Health (Grant No. K02 NS089852 to C.D.S., K23 MH105179 to C.E.R., F30 HD105336 to P.E.P.C., R01 MH113570 to C.D.S. and C.E.R., K01 MH122735 to R.E.L., P30 NS098577 , R01 HD061619 , R01 HD057098 , P50 HD103525 (to J.S.S., C.D.S. and C.E.R.), GM07200); the Child Neurology Foundation , Lexington, KY (to C.D.S.); Cerebral Palsy International Research Foundation , Princeton Junction, NJ (to C.D.S.); and March of Dimes , Arlington, VA (to C.D.S.). The funding sources had no involvement in the design, data collection, analysis, interpretation, writing of the report or decision to submit this article for publication. Funding Information: We would like to thank Abraham Snyder, Karen Lukas, Karen Lob, Anthony Barton, Rachel Paul, and Jessica Perkins for study coordination, and the children and families for participating in the study. Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award Number P50 HD103525 to the Intellectual and Developmental Disabilities Research Center at Washington University. Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = jan,
doi = "10.1016/j.nicl.2022.103260",
language = "English",
volume = "36",
journal = "NeuroImage: Clinical",
issn = "2213-1582",
}