TY - JOUR
T1 - Neonatal development of intestinal neuroimmune interactions
AU - Schill, Ellen Merrick
AU - Floyd, Alexandria N.
AU - Newberry, Rodney D.
N1 - Funding Information:
We want to thank Shreya Gaddipati, Vini John, Keely G. McDonald, and the members of the Newberry lab for their assistance in preparing this manuscript. BioRender ( Biorender.com ) was used to generate the figures. This work was supported, in part, by grants NIH R01DK097317 (R.D.N.), NIH R01AI173220 (R.D.N.), NIH U01AI163073 (R.D.N.), NIH T32DK077653-30 (E.M.S.), NIH T32HD43010-20 (E.M.S.), and the American Academy of Pediatrics Marshal Klaus Award 2022 . The Washington University in St Louis School of Medicine Digestive Diseases Research Cores Center is supported by grant NIH P30DK52574 .
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/12
Y1 - 2022/12
N2 - Interactions between the enteric nervous system (ENS), immune system, and gut microbiota regulate intestinal homeostasis in adults, but their development and role(s) in early life are relatively underexplored. In early life, these interactions are dynamic, because the mucosal immune system, microbiota, and the ENS are developing and influencing each other. Moreover, disrupting gut microbiota and gut immune system development, and potentially ENS development, by early-life antibiotic exposure increases the risk of diseases affecting the gut. Here, we review the development of the ENS and immune/epithelial cells, and identify potential critical periods for their interactions and development. We also highlight knowledge gaps that, when addressed, may help promote intestinal homeostasis, including in the settings of early-life antibiotic exposure.
AB - Interactions between the enteric nervous system (ENS), immune system, and gut microbiota regulate intestinal homeostasis in adults, but their development and role(s) in early life are relatively underexplored. In early life, these interactions are dynamic, because the mucosal immune system, microbiota, and the ENS are developing and influencing each other. Moreover, disrupting gut microbiota and gut immune system development, and potentially ENS development, by early-life antibiotic exposure increases the risk of diseases affecting the gut. Here, we review the development of the ENS and immune/epithelial cells, and identify potential critical periods for their interactions and development. We also highlight knowledge gaps that, when addressed, may help promote intestinal homeostasis, including in the settings of early-life antibiotic exposure.
KW - early-life antibiotics
KW - enteric nervous system
KW - goblet cells
KW - innate lymphoid cells
KW - muscularis macrophages
KW - neonatal microbiome
UR - http://www.scopus.com/inward/record.url?scp=85141002737&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2022.10.002
DO - 10.1016/j.tins.2022.10.002
M3 - Review article
C2 - 36404456
AN - SCOPUS:85141002737
VL - 45
SP - 928
EP - 941
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0166-2236
IS - 12
ER -