TY - JOUR
T1 - Neonatal brain abnormalities and memory and learning outcomes at 7 years in children born very preterm
AU - Omizzolo, Cristina
AU - Scratch, Shannon E.
AU - Stargatt, Robyn
AU - Kidokoro, Hiroyuki
AU - Thompson, Deanne K.
AU - Lee, Katherine J.
AU - Cheong, Jeanie
AU - Neil, Jeffrey
AU - Inder, Terrie E.
AU - Doyle, Lex W.
AU - Anderson, Peter J.
N1 - Funding Information:
Address correspondence to: Dr Peter Anderson, Victorian Infant Brain Studies (VIBeS), Murdoch Childrens Research Institute, Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia. E-mail: [email protected] We would like to acknowledge the input of the entire VIBeS research team, and all the families who participated in this study. This study was funded by Australia’s National Health & Medical Research Council*Project Grants (237117 & 491209), Early Career Award (1012236 to D.T.), Senior Research Fellowship (628371 to P.A.)*National Institutes of Health (HD058056), and the Victorian Government’s Operational Infrastructure Support Program.
PY - 2014/8
Y1 - 2014/8
N2 - Using prospective longitudinal data from 198 very preterm and 70 full term children, this study characterised the memory and learning abilities of very preterm children at 7 years of age in both verbal and visual domains. The relationship between the extent of brain abnormalities on neonatal magnetic resonance imaging (MRI) and memory and learning outcomes at 7 years of age in very preterm children was also investigated. Neonatal MRI scans were qualitatively assessed for global, white-matter, cortical grey-matter, deep grey-matter, and cerebellar abnormalities. Very preterm children performed less well on measures of immediate memory, working memory, long-term memory, and learning compared with term-born controls. Neonatal brain abnormalities, and in particular deep grey-matter abnormality, were associated with poorer memory and learning performance at 7 years in very preterm children. Findings support the importance of cerebral neonatal pathology for predicting later memory and learning function.
AB - Using prospective longitudinal data from 198 very preterm and 70 full term children, this study characterised the memory and learning abilities of very preterm children at 7 years of age in both verbal and visual domains. The relationship between the extent of brain abnormalities on neonatal magnetic resonance imaging (MRI) and memory and learning outcomes at 7 years of age in very preterm children was also investigated. Neonatal MRI scans were qualitatively assessed for global, white-matter, cortical grey-matter, deep grey-matter, and cerebellar abnormalities. Very preterm children performed less well on measures of immediate memory, working memory, long-term memory, and learning compared with term-born controls. Neonatal brain abnormalities, and in particular deep grey-matter abnormality, were associated with poorer memory and learning performance at 7 years in very preterm children. Findings support the importance of cerebral neonatal pathology for predicting later memory and learning function.
KW - Gestational age
KW - Memory and learning
KW - Neonatal brain abnormalities
KW - Very preterm
UR - http://www.scopus.com/inward/record.url?scp=84898539392&partnerID=8YFLogxK
U2 - 10.1080/09658211.2013.809765
DO - 10.1080/09658211.2013.809765
M3 - Article
C2 - 23805915
AN - SCOPUS:84898539392
SN - 0965-8211
VL - 22
SP - 605
EP - 615
JO - Memory
JF - Memory
IS - 6
ER -