Neonatal auditory activation detected by functional magnetic resonance imaging

Adam W. Anderson; Rene Marois; Eve R. Colson; Bradley S. Peterson; Charles C. Duncan; Richard A. Ehrenkranz; Karen C. Schneider; John C. Gore; Laura R. Ment

doi:10.1016/S0730-725X(00)00231-9

Neonatal auditory activation detected by functional magnetic resonance imaging

Adam W. Anderson, Rene Marois, Eve R. Colson, Bradley S. Peterson, Charles C. Duncan, Richard A. Ehrenkranz, Karen C. Schneider, John C. Gore, Laura R. Ment

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

The objective of this study was to detect auditory cortical activation in non-sedated neonates employing functional magnetic resonance imaging (fMRI). Using echo-planar functional brain imaging, subjects were presented with a frequency-modulated pure tone; the BOLD signal response was mapped in 5 mm-thick slices running parallel to the superior temporal gyrus. Twenty healthy neonates (13 term, 7 preterm) at term and 4 adult control subjects. Blood oxygen level-dependent (BOLD) signal in response to auditory stimulus was detected in all 4 adults and in 14 of the 20 neonates. FMRI studies of adult subjects demonstrated increased signal in the superior temporal regions during auditory stimulation. In contrast, signal decreases were detected during auditory stimulation in 9 of 14 newborns with BOLD response. fMRI can be used to detect brain activation with auditory stimulation in human infants.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Magnetic Resonance Imaging
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/S0730-725X(00)00231-9
State	Published - 2001

Keywords

Auditory cortex
Functional magnetic resonance imaging
Neonate
Term

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10.1016/S0730-725X(00)00231-9

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@article{933772d805fa41b9bb5598c599403eff,

title = "Neonatal auditory activation detected by functional magnetic resonance imaging",

abstract = "The objective of this study was to detect auditory cortical activation in non-sedated neonates employing functional magnetic resonance imaging (fMRI). Using echo-planar functional brain imaging, subjects were presented with a frequency-modulated pure tone; the BOLD signal response was mapped in 5 mm-thick slices running parallel to the superior temporal gyrus. Twenty healthy neonates (13 term, 7 preterm) at term and 4 adult control subjects. Blood oxygen level-dependent (BOLD) signal in response to auditory stimulus was detected in all 4 adults and in 14 of the 20 neonates. FMRI studies of adult subjects demonstrated increased signal in the superior temporal regions during auditory stimulation. In contrast, signal decreases were detected during auditory stimulation in 9 of 14 newborns with BOLD response. fMRI can be used to detect brain activation with auditory stimulation in human infants.",

keywords = "Auditory cortex, Functional magnetic resonance imaging, Neonate, Term",

author = "Anderson, {Adam W.} and Rene Marois and Colson, {Eve R.} and Peterson, {Bradley S.} and Duncan, {Charles C.} and Ehrenkranz, {Richard A.} and Schneider, {Karen C.} and Gore, {John C.} and Ment, {Laura R.}",

note = "Funding Information: Supported by NS 27116, NS 33332, and NS 35476 of the National Institute of Neurologic Disorders and Stroke, MH 01232 of the National Institute of Mental Health, and RR 06022 of the National Center of Research Resources ",

year = "2001",

doi = "10.1016/S0730-725X(00)00231-9",

language = "English",

volume = "19",

pages = "1--5",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

number = "1",

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T1 - Neonatal auditory activation detected by functional magnetic resonance imaging

AU - Anderson, Adam W.

AU - Marois, Rene

AU - Colson, Eve R.

AU - Peterson, Bradley S.

AU - Duncan, Charles C.

AU - Ehrenkranz, Richard A.

AU - Schneider, Karen C.

AU - Gore, John C.

AU - Ment, Laura R.

N1 - Funding Information: Supported by NS 27116, NS 33332, and NS 35476 of the National Institute of Neurologic Disorders and Stroke, MH 01232 of the National Institute of Mental Health, and RR 06022 of the National Center of Research Resources

PY - 2001

Y1 - 2001

N2 - The objective of this study was to detect auditory cortical activation in non-sedated neonates employing functional magnetic resonance imaging (fMRI). Using echo-planar functional brain imaging, subjects were presented with a frequency-modulated pure tone; the BOLD signal response was mapped in 5 mm-thick slices running parallel to the superior temporal gyrus. Twenty healthy neonates (13 term, 7 preterm) at term and 4 adult control subjects. Blood oxygen level-dependent (BOLD) signal in response to auditory stimulus was detected in all 4 adults and in 14 of the 20 neonates. FMRI studies of adult subjects demonstrated increased signal in the superior temporal regions during auditory stimulation. In contrast, signal decreases were detected during auditory stimulation in 9 of 14 newborns with BOLD response. fMRI can be used to detect brain activation with auditory stimulation in human infants.

AB - The objective of this study was to detect auditory cortical activation in non-sedated neonates employing functional magnetic resonance imaging (fMRI). Using echo-planar functional brain imaging, subjects were presented with a frequency-modulated pure tone; the BOLD signal response was mapped in 5 mm-thick slices running parallel to the superior temporal gyrus. Twenty healthy neonates (13 term, 7 preterm) at term and 4 adult control subjects. Blood oxygen level-dependent (BOLD) signal in response to auditory stimulus was detected in all 4 adults and in 14 of the 20 neonates. FMRI studies of adult subjects demonstrated increased signal in the superior temporal regions during auditory stimulation. In contrast, signal decreases were detected during auditory stimulation in 9 of 14 newborns with BOLD response. fMRI can be used to detect brain activation with auditory stimulation in human infants.

KW - Auditory cortex

KW - Functional magnetic resonance imaging

KW - Neonate

KW - Term

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DO - 10.1016/S0730-725X(00)00231-9

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SN - 0730-725X

VL - 19

SP - 1

EP - 5

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 1

ER -

Neonatal auditory activation detected by functional magnetic resonance imaging

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Keywords

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