Neoadjuvant endocrine therapy in primary breast cancer: Indications and use as a research tool

Y. H. Chia, M. J. Ellis, C. X. Ma

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

Neoadjuvant endocrine therapy has been increasingly employed in clinical practice to improve surgical options for postmenopausal women with bulky hormone receptor-positive breast cancer. Recent studies indicate that tumour response in this setting may predict long-term outcome of patients on adjuvant endocrine therapy, which argues for its broader application in treating hormone receptor-positive disease. From the research perspective, neoadjuvant endocrine therapy provides a unique opportunity for studies of endocrine responsiveness and the development of novel therapeutic agents.

Original languageEnglish
Pages (from-to)759-764
Number of pages6
JournalBritish Journal of Cancer
Volume103
Issue number6
DOIs
StatePublished - Sep 7 2010

Keywords

  • breast cancer
  • genomics
  • neoadjuvant endocrine therapy
  • oestrogen receptor
  • relapse risk

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