Neoadjuvant endocrine therapy for breast cancer

Jane S. Chawla, Cynthia X. Ma, Matthew J. Ellis

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Neoadjuvant endocrine therapy improves surgical outcomes for postmenopausal women with bulky hormone receptor-positive breast cancer. Recent studies indicate that this approach may also be used in the management of smaller tumors with the hope of predicting outcomes from adjuvant endocrine manipulation. Neoadjuvant endocrine therapy provides a unique opportunity to identify molecular predictors of endocrine responsiveness and agents that can be used in combination with endocrine therapy to improve tumor response and overcome endocrine resistance.

Original languageEnglish
Pages (from-to)627-638
Number of pages12
JournalSurgical Oncology Clinics of North America
Issue number3
StatePublished - Jul 2010


  • Breast cancer
  • Estrogen receptor
  • Genomics
  • Neoadjuvant endocrine therapy
  • Relapse risk


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