Background: Oral cavity cancer (OCC) and laryngeal cancer cancer survival for NH White, NH Black, Hispanic, and Asian are among the most common cancers worldwide. This study patients. In the multivariable analyses of both OCC and laryngeal investigated survival in non-Hispanic (NH) Black, NH White, cancer survival, NH Black patients had worse survival than NH Asian, and Hispanic patients with OCC and laryngeal cancer of White patients in the high nSES tertile. NH Black patients with OCC low, intermediate, and high neighborhood socioeconomic status were at higher risk of death than NH White patients at all nSES (nSES). levels. Conversely, Asian patients with laryngeal cancer demon-Methods: We used data from the SEER 18 Census Tract-level SES strated better survival than other races within the high nSES. and Rurality Database of the National Cancer Institute to create Conclusions: Overall survival differs between racial and ethnic cohorts of OCC and laryngeal cancer patients from 2013 to 2018. groups of similar nSESs. These health disparities in patients with Univariate survival analysis was performed with Kaplan–Meier OCC and laryngeal cancer reflect broader inequities in the cancer curves and log-rank P values by nSES and then the cross-control continuum. classification of race, ethnicity, and nSES. We used Cox proporImpact: The cross-classification of race, ethnicity, and nSES tional hazards regression model for multivariable analysis. revealed disparities in the 5-year overall survival of patients with Results: Higher nSES was associated with better OCC survival for OCC and laryngeal cancer and highlights the importance of inter-NH White, NH Black, and Asian patients, and better laryngeal sectionality in the discussion of health equity.