@article{8368867fa974446e9553901c7375c554,
title = "Nef: Agent of cell subversion",
abstract = "Primate lentiviruses encode a small protein designated Nef that has been shown to be a major determinant of virus pathogenicity. Nef regulates multiple host factors in order to optimize the cellular environment for virus replication. The mechanisms by which this small protein modulates distinct host cell properties provide intriguing insight into the intricate interaction between virus and host.",
keywords = "Acquired Immunodeficiency Syndrome, Antigens, CD4, Gene products, nef, Genes, nef, HIV, HLA antigens, P21-activated kinase 2, SIV",
author = "Arora, {Vivek K.} and Fredericksen, {Brenda L.} and Garcia, {J. Victor}",
note = "Funding Information: We thank Simon Daefler and John Foster for critically reading this manuscript and for helpful discussions during its preparation. We also thank all members of the Garcia laboratory for their helpful suggestions. V.K.A. is supported in part by funds from the National Cancer Institute from the Cancer Immunology Training Grant 5 T32 CA09082. This work was supported by grant AI33331 from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health.",
year = "2002",
doi = "10.1016/S1286-4579(01)01527-1",
language = "English",
volume = "4",
pages = "189--199",
journal = "Microbes and Infection",
issn = "1286-4579",
number = "2",
}