TY - JOUR
T1 - Neck Rhabdoid Tumors
T2 - Clinical Features and Consideration of Autologous Stem Cell Transplant
AU - Wolfe, Adam D.
AU - Capitini, Christian M.
AU - Salamat, Shahriar M.
AU - DeSantes, Kenneth
AU - Bradley, Kristin A.
AU - Kennedy, Tabassum
AU - Dehner, Louis P.
AU - Patel, Neha J.
N1 - Funding Information:
Supported by NIH/NHLBI T32 HL07899 and NIH NOT-OD-11-086 (A.D.W.). NIH/NCI K08 CA174750 (C.M.C.).
Funding Information:
Supported by NIH/NHLBI T32 HL07899 and NIH NOT-OD-11-086 (A.D.W.). NIH/NCI K08 CA174750 (C.M.C.)
Publisher Copyright:
© Copyright 2017 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Summary: Extrarenal malignant rhabdoid tumors (MRT) have a poor prognosis despite aggressive therapy. Adding high-dose chemotherapy with autologous stem cell rescue (HDC-ASCR) as consolidative therapy for MRT is controversial. We describe 2 patients, age 13 years and 19 months, with unresectable neck MRT. After chemotherapy and radiotherapy, both underwent HDC-ASCR and remain in remission over 4 years later. We reviewed all published cases of neck MRT, and found poorer outcomes and more variable age of presentation and time to progression than MRT at other sites. Neck MRT may represent a higher-risk subset of MRT, and addition of HDC-ASCR merits consideration.
AB - Summary: Extrarenal malignant rhabdoid tumors (MRT) have a poor prognosis despite aggressive therapy. Adding high-dose chemotherapy with autologous stem cell rescue (HDC-ASCR) as consolidative therapy for MRT is controversial. We describe 2 patients, age 13 years and 19 months, with unresectable neck MRT. After chemotherapy and radiotherapy, both underwent HDC-ASCR and remain in remission over 4 years later. We reviewed all published cases of neck MRT, and found poorer outcomes and more variable age of presentation and time to progression than MRT at other sites. Neck MRT may represent a higher-risk subset of MRT, and addition of HDC-ASCR merits consideration.
KW - Atypical teratoid rhabdoid tumor
KW - High-dose chemotherapy with autologous stem cell rescue
KW - Malignant rhabdoid tumor
UR - http://www.scopus.com/inward/record.url?scp=85017148018&partnerID=8YFLogxK
U2 - 10.1097/MPH.0000000000000829
DO - 10.1097/MPH.0000000000000829
M3 - Article
C2 - 28375943
AN - SCOPUS:85017148018
SN - 1077-4114
VL - 40
SP - e50-e54
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
IS - 1
ER -