Near-patient platelet function testing in patients undergoing coronary artery surgery: A pilot study

M. J. Reece, A. A. Klein, E. A. Salviz, A. Hastings, A. Ashworth, C. Freeman, R. J. Luddington, S. Nair, M. W. Besser

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Platelet dysfunction after cardiopulmonary bypass contributes to microvascular bleeding and is associated with blood transfusion and resternotomy. Platelet count can be readily performed, but currently there are no standardised, reproducible, rapidly available platelet function tests. We studied platelet function as measured by multiple electrode platelet aggregometery (multiplate) and light transmission aggregometry in 44 patients undergoing routine coronary artery surgery. Platelet aggregation as measured by multiplate was reduced during and after cardiopulmonary bypass compared with baseline with evidence of partial recovery by the time of transfer to ITU. In patients transfused blood, platelet aggregation measured by multiplate was reduced during chest closure with adenosine diphosphate (18 U vs 29 U, p = 0.01) and thrombin receptor agonist peptide-6 agonist (65 U vs 88 U, p = 0.01) compared with patients not transfused. This suggests that multiplate, a new point of care analyser, can detect platelet dysfunction in this setting.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalAnaesthesia
Volume66
Issue number2
DOIs
StatePublished - Feb 2011

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