Near infrared spectral polarization imaging of prostate cancer tissues using Cybesin: A receptor-targeted contrast agent

Yang Pu, W. B. Wang, G. C. Tang, Kexian Liang, S. Achilefu, R. R. Alfano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cybesin, a smart contrast agent to target cancer cells, was investigated using a near infrared (NIR) spectral polarization imaging technique for prostate cancer detection. The approach relies on applying a contrast agent that can target cancer cells. Cybesin, as a small ICG-derivative dye-peptide, emit fluorescence between 750 nm and 900 nm, which is in the "tissue optical window". Cybesin was reported targeting the over-expressed bombesin receptors in cancer cells in animal model and the human prostate cancers over-expressing bombesin receptors. The NIR spectral polarization imaging study reported here demonstrated that Cybesin can be used as a smart optical biomarker and as a prostate cancer receptor targeted contrast agent.

Original languageEnglish
Title of host publicationPhotonic Therapeutics and Diagnostics IX
DOIs
StatePublished - May 30 2013
EventPhotonic Therapeutics and Diagnostics IX - San Francisco, CA, United States
Duration: Feb 2 2013Feb 7 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8565
ISSN (Print)1605-7422

Conference

ConferencePhotonic Therapeutics and Diagnostics IX
CountryUnited States
CitySan Francisco, CA
Period02/2/1302/7/13

Keywords

  • Absorption, and fluorescence
  • Contrast agent
  • Cybesin
  • Near-infrared (NIR)
  • Peptide analogue conjugate
  • Prostate cancer
  • Receptor-targeted
  • Spectral polarization imaging

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  • Cite this

    Pu, Y., Wang, W. B., Tang, G. C., Liang, K., Achilefu, S., & Alfano, R. R. (2013). Near infrared spectral polarization imaging of prostate cancer tissues using Cybesin: A receptor-targeted contrast agent. In Photonic Therapeutics and Diagnostics IX [85651G] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8565). https://doi.org/10.1117/12.2000079