Near-infrared light-triggered dissociation of block copolymer micelles for controlled drug release

Jie Cao, Shanshan Huang, Yuqi Chen, Siwen Li, Samuel Achilefu, Zhiyu Qian, Yueqing Gu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this manuscript, a new near-infrared (NIR) light-breakable amphiphilic block copolymer containing light-sensitive triggering group on the hydrophobic block was developed. By encapsulating NIR dye cypate inside micelles of poly (N-succinyl-N′-4- (2-nitrobenzyloxy)-succinyl chitosan) and exposing the micellar solution to 765.9 nm light, the photo-cleavage reaction was activated and leading to the dissociation of micelles and release of co-loaded hydrophobic species. The UV-vis absorption spectra, fourier transform infrared (FTIR) spectra and 1H nuclear magnetic resonance (1H NMR) spectra of micelles were characterized. Triggered burst release of the payload upon NIR irradiation and subsequent degradation of the micelles were observed by transmission electron microscopy (TEM). This system represents a general and efficient method to circumvent the need for UV or visible light excitation that is a common drawback for light-responsive polymeric systems developed for potential biomedical applications.

Original languageEnglish
Title of host publicationReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V
DOIs
StatePublished - May 30 2013
EventReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V - San Francisco, CA, United States
Duration: Feb 4 2013Feb 6 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8596
ISSN (Print)1605-7422

Conference

ConferenceReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V
CountryUnited States
CitySan Francisco, CA
Period02/4/1302/6/13

Keywords

  • NIR light
  • controlled release
  • drug delivery
  • micelles

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  • Cite this

    Cao, J., Huang, S., Chen, Y., Li, S., Achilefu, S., Qian, Z., & Gu, Y. (2013). Near-infrared light-triggered dissociation of block copolymer micelles for controlled drug release. In Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V [859606] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8596). https://doi.org/10.1117/12.2003247