TY - JOUR
T1 - Near infrared light controlled gene editing
AU - Berezin, Mikhail Y.
N1 - Publisher Copyright:
© The Author(s) 2026.
PY - 2026/12
Y1 - 2026/12
N2 - A novel NIR light-activated CRISPR-dCas9/Cas9 system achieves precise and rapid gene regulation in living organism using a chemically cleavable rapamycin dimer. Unlike previous light-driven systems, this approach offers deeper tissue penetration, low toxicity, fast response, and minimal background activity. This platform opens new directions for highly efficient, targeted, noninvasive, and spatially confined gene editing for a great number of preclinical and clinically translatable applications.
AB - A novel NIR light-activated CRISPR-dCas9/Cas9 system achieves precise and rapid gene regulation in living organism using a chemically cleavable rapamycin dimer. Unlike previous light-driven systems, this approach offers deeper tissue penetration, low toxicity, fast response, and minimal background activity. This platform opens new directions for highly efficient, targeted, noninvasive, and spatially confined gene editing for a great number of preclinical and clinically translatable applications.
UR - https://www.scopus.com/pages/publications/105026585468
U2 - 10.1038/s41377-025-02128-x
DO - 10.1038/s41377-025-02128-x
M3 - Comment/debate
C2 - 41486166
AN - SCOPUS:105026585468
SN - 2095-5545
VL - 15
JO - Light: Science and Applications
JF - Light: Science and Applications
IS - 1
M1 - 55
ER -