Near-infrared fluorescent ph-sensitive probes via unexpected barbituric acid mediated synthesis

Hyeran Lee, Mikhail Y. Berezin, Kevin Guo, Jeff Kao, Samuel Achilefu

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Novel near-infrared pyrimidine-fused pH fluorescent probes were prepared by an unusual barbiturate-mediated debenzoindolation and subsequent heteroannulation. A plausible mechanistic pathway is proposed, and the final structures were further elucidated by 2D-NMR. All new compounds are highly fluorescent in the near-infrared region and possess excellent spectral sensitivities to environmental pH changes.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalOrganic Letters
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2009

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