@article{26c521aae7344bd6a49254cd462ce8d7,
title = "Near-infrared fluorescence goggle system with complementary metal-oxide-semiconductor imaging sensor and see-through display",
abstract = "We have developed a near-infrared (NIR) fluorescence goggle system based on the complementary metal-oxide-semiconductor active pixel sensor imaging and see-through display technologies. The fluorescence goggle system is a compact wearable intraoperative fluorescence imaging and display system that can guide surgery in real time. The goggle is capable of detecting fluorescence of indocyanine green solution in the picomolar range. Aided by NIR quantum dots, we successfully used the fluorescence goggle to guide sentinel lymph node mapping in a rat model. We further demonstrated the feasibility of using the fluorescence goggle in guiding surgical resection of breast cancer metastases in the liver in conjunction with NIR fluorescent probes. These results illustrate the diverse potential use of the goggle system in surgical procedures.",
keywords = "cancer surgery imaging molecular probe quantum dots",
author = "Yang Liu and Raphael Njuguna and Thomas Matthews and Akers, {Walter J.} and Sudlow, {Gail P.} and Suman Mondal and Rui Tang and Viktor Gruev and Samuel Achilefu",
note = "Funding Information: This study was supported in part by grants from the National Institutes of Health (NCI R01 CA171651 and NIBIB R01 EB008111; Samuel Achilefu) as well as the Air Force Office of Scientific Research (FA9550-10-1-0121 and FA9550-12-1-0321; Viktor Gruev). Yang Liu was supported by the US Department of Defense Breast Cancer Research Program Predoctoral Award (W81XWH-11-1-0059). Walter Akers was supported by Award Number K01RR026095 from the National Center for Research Resources. We thank Mrs. Kexian Liang for preparing LS301. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health and the Department of Defense.",
year = "2013",
doi = "10.1117/1.JBO.18.10.101303",
language = "English",
volume = "18",
journal = "Journal of biomedical optics",
issn = "1083-3668",
number = "10",
}