TY - JOUR
T1 - NCAM1 supports therapy resistance and LSC function in AML
AU - Sykes, Stephen M.
N1 - Funding Information:
Conflict-of-interest disclosure: P.M.M. owns stock in Autolus Ltd. M.A.P. owns stock in and receives salary contribution and research funding from Autolus Ltd. n
Publisher Copyright:
© 2019 by The American Society of Hematology.
PY - 2019/5/23
Y1 - 2019/5/23
N2 - In this issue of Blood, Sasca et al present intriguing data that the cell surface marker NCAM1 (neural cell adhesion molecule 1, also known as CD56), which is expressed in approximately 15% to 20% of acute myeloid leukemia (AML) cases, promotes chemotherapy resistance and leukemia stem cell (LSC, also referred to as a leukemia initiating cell) function, in part through activation of the MAPK signaling cascade (see figure). Notably, they provide data that pharmacologic inhibitors of the MAPK pathway synergistically cooperate with cytarabine (Ara-C) in eliminating NCAM1-expressing AML cells, suggesting that NCAM1 may represent both a potential targetable vulnerability and a biomarker for guiding treatment decisions in AML.
AB - In this issue of Blood, Sasca et al present intriguing data that the cell surface marker NCAM1 (neural cell adhesion molecule 1, also known as CD56), which is expressed in approximately 15% to 20% of acute myeloid leukemia (AML) cases, promotes chemotherapy resistance and leukemia stem cell (LSC, also referred to as a leukemia initiating cell) function, in part through activation of the MAPK signaling cascade (see figure). Notably, they provide data that pharmacologic inhibitors of the MAPK pathway synergistically cooperate with cytarabine (Ara-C) in eliminating NCAM1-expressing AML cells, suggesting that NCAM1 may represent both a potential targetable vulnerability and a biomarker for guiding treatment decisions in AML.
UR - http://www.scopus.com/inward/record.url?scp=85066831464&partnerID=8YFLogxK
U2 - 10.1182/blood-2019-03-901017
DO - 10.1182/blood-2019-03-901017
M3 - Review article
C2 - 31122937
AN - SCOPUS:85066831464
SN - 0006-4971
VL - 133
SP - 2247
EP - 2248
JO - Blood
JF - Blood
IS - 21
ER -