TY - JOUR
T1 - Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase
AU - Williams, Karen D.
AU - Busto, Macarena
AU - Suster, Maximiliano L.
AU - So, Anthony K.C.
AU - Ben-Shahar, Yehuda
AU - Leevers, Sally J.
AU - Sokolowski, Marla B.
PY - 2006/10/24
Y1 - 2006/10/24
N2 - This study links natural variation in a Drosophila melanogaster overwintering strategy, diapause, to the insulin-regulated phosphatidylinositol 3-kinase (PI3-kinase) gene, Dp110. Variation in diapause, a reproductive arrest, was associated with Dp110 by using Dp110 deletions and genomic rescue fragments in transgenic flies. Deletions of Dp110 increased the proportion of individuals in diapause, whereas expression of Dp110 in the nervous system, but not including the visual system, decreased it. The roles of phosphatidylinositol 3-kinase for both diapause in D. melanogaster and dauer formation in Caenorhabditis elegans suggest a conserved role for this kinase in both reproductive and developmental arrests in response to environmental stresses.
AB - This study links natural variation in a Drosophila melanogaster overwintering strategy, diapause, to the insulin-regulated phosphatidylinositol 3-kinase (PI3-kinase) gene, Dp110. Variation in diapause, a reproductive arrest, was associated with Dp110 by using Dp110 deletions and genomic rescue fragments in transgenic flies. Deletions of Dp110 increased the proportion of individuals in diapause, whereas expression of Dp110 in the nervous system, but not including the visual system, decreased it. The roles of phosphatidylinositol 3-kinase for both diapause in D. melanogaster and dauer formation in Caenorhabditis elegans suggest a conserved role for this kinase in both reproductive and developmental arrests in response to environmental stresses.
KW - Evolutionary genetics
UR - https://www.scopus.com/pages/publications/33750483929
U2 - 10.1073/pnas.0604592103
DO - 10.1073/pnas.0604592103
M3 - Article
C2 - 17043223
AN - SCOPUS:33750483929
SN - 0027-8424
VL - 103
SP - 15911
EP - 15915
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 43
ER -