TY - JOUR
T1 - Natural Products for the Treatment of Pain
T2 - Chemistry and Pharmacology of Salvinorin A, Mitragynine, and Collybolide
AU - Chakraborty, Soumen
AU - Majumdar, Susruta
N1 - Funding Information:
S.M. is supported by funds from NIH grants DA045884, DA046487, and DA048379 and start-up funds from the Center for Clinical Pharmacology, St. Louis College of Pharmacy, and Washington University.
Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.
PY - 2021/5/11
Y1 - 2021/5/11
N2 - Pain remains a very pervasive problem throughout medicine. Classical pain management is achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which have significant side effects that hinder their utility. Pharmacologists have been trying to develop opioids devoid of side effects since the isolation of morphine from papaver somniferum, more commonly known as opium by Sertürner in 1804. The natural products salvinorin A, mitragynine, and collybolide represent three nonmorphinan natural product-based targets, which are potent selective agonists of opioid receptors, and emerging next-generation analgesics. In this work, we review the phytochemistry and medicinal chemistry efforts on these templates and their effects on affinity, selectivity, analgesic actions, and a myriad of other opioid-receptor-related behavioral effects.
AB - Pain remains a very pervasive problem throughout medicine. Classical pain management is achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which have significant side effects that hinder their utility. Pharmacologists have been trying to develop opioids devoid of side effects since the isolation of morphine from papaver somniferum, more commonly known as opium by Sertürner in 1804. The natural products salvinorin A, mitragynine, and collybolide represent three nonmorphinan natural product-based targets, which are potent selective agonists of opioid receptors, and emerging next-generation analgesics. In this work, we review the phytochemistry and medicinal chemistry efforts on these templates and their effects on affinity, selectivity, analgesic actions, and a myriad of other opioid-receptor-related behavioral effects.
UR - http://www.scopus.com/inward/record.url?scp=85096621759&partnerID=8YFLogxK
U2 - 10.1021/acs.biochem.0c00629
DO - 10.1021/acs.biochem.0c00629
M3 - Review article
C2 - 32930582
AN - SCOPUS:85096621759
SN - 0006-2960
VL - 60
SP - 1381
EP - 1400
JO - Biochemistry
JF - Biochemistry
IS - 18
ER -