Natural killer-type receptors for HLA class I antigens are clonally expressed in lymphoproliferative disorders of natural killer and T-cell type

T. Hoffmann, G. De Libero, M. Colonna, A. Wodnar-Filipowicz, J. Passweg, G. Favre, A. Gratwohl, A. Tichelli

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

In recent years, natural killer (NK) cells, as well as subpopulations of T cells, have been found to express diverse NK receptors (NKRs) for HLA class I molecules. We have characterized NKR phenotypes in lymphoproliferative disorders of NK or T-cell type. Peripheral blood of patients with lymphoproliferative disorders (n = 9) was analysed by multiparametric immunofluorescence flow cytometry with eight different antibodies against NKRs. Abnormal neoplastic cell populations from different types of NK or T-cell lymphoproliferative disorders lacked diversity in their NKR repertoires, i.e. all or none of the abnormal cells expressed individual NKRs and this expression occurred at single levels of intensity. This pattern of expression was specific for lymphoproliferative disorders as these resticted NKR repertoires were not found either in healthy donors (n = 9) or in patients with viral or autoimmune disease (n = 5). We conclude that NKRs are clonally expressed in lymphoproliferative disorders of NK or T-cell origin. NKR repertoires may represent a novel tool in diagnosing clonal disorders of NK and T-cell type.

Original languageEnglish
Pages (from-to)525-537
Number of pages13
JournalBritish Journal of Haematology
Volume110
Issue number3
DOIs
StatePublished - 2000

Keywords

  • Clonality
  • Diagnosis
  • HLA receptor
  • Lymphoproliferative disorder
  • Natural killer

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