TY - JOUR
T1 - Natural killer clones recognize specific soluble HLA class I molecules
AU - Carbone, Ennio
AU - Terrazzano, Giuseppe
AU - Colonna, Marco
AU - Tuosto, Loretta
AU - Piccolella, Enza
AU - Franksson, Lars
AU - Palazzolo, Giovanni
AU - Pérez-Villar, Juan José
AU - Fontana, Silvia
AU - Kärre, Klas
AU - Zappacosta, Serafino
PY - 1996/3
Y1 - 1996/3
N2 - Enhancement of major histocompatibility complex (MHC) class I expression leads to protection from natural killer (NK) cell recognition in several systems. MHC class I gene products are released from the cell surface and can be found in sera as soluble forms. To investigate the possible immunoregulatory role of soluble HLA (sHLA) in NK cell-target recognition, several sHLA antigens were studied for their ability to induce NK cell cytotoxicity modulation. NK cell-target recognition was inhibited by the addition of sHLA during the cytotoxicity assay. Our results indicate that sHLA molecules can down-regulate NK killing at the effector level. Moreover, different NK clones are able to specifically recognize different sHLA antigens. Kp43 molecules seem to be involved in the NK recognition of sHLA-B7.
AB - Enhancement of major histocompatibility complex (MHC) class I expression leads to protection from natural killer (NK) cell recognition in several systems. MHC class I gene products are released from the cell surface and can be found in sera as soluble forms. To investigate the possible immunoregulatory role of soluble HLA (sHLA) in NK cell-target recognition, several sHLA antigens were studied for their ability to induce NK cell cytotoxicity modulation. NK cell-target recognition was inhibited by the addition of sHLA during the cytotoxicity assay. Our results indicate that sHLA molecules can down-regulate NK killing at the effector level. Moreover, different NK clones are able to specifically recognize different sHLA antigens. Kp43 molecules seem to be involved in the NK recognition of sHLA-B7.
KW - Natural killer cell clones
KW - Natural killer cell sensitivity
KW - Natural killer receptors
KW - Soluble HLA class I antigens
UR - http://www.scopus.com/inward/record.url?scp=13344249754&partnerID=8YFLogxK
U2 - 10.1002/eji.1830260326
DO - 10.1002/eji.1830260326
M3 - Article
C2 - 8605938
AN - SCOPUS:13344249754
SN - 0014-2980
VL - 26
SP - 683
EP - 689
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 3
ER -