TY - JOUR
T1 - Natural killer cells and viral infections
AU - French, Anthony R.
AU - Yokoyama, Wayne M.
N1 - Funding Information:
A French is supported by a National Institutes of Health training grant and Washington University through funds from the Howard Hughes Medical Institute. Work in the Yokoyama laboratory is supported by grants from the National Institute of Allergy and Infectious Diseases and by the Barnes-Jewish Hospital Foundation and the Howard Hughes Medical Institute.
PY - 2003/2
Y1 - 2003/2
N2 - Natural killer (NK) cells play a key role in innate host defense against viruses. Significant progress has been made in understanding the specific response of NK cells during viral infections by the recent identification of an NK cell receptor involved in in vivo resistance, and its ligand. New insight has also been provided in NK cell cytokine and chemokine responses, highlighting the complexity of regulatory pathways. Taken together, a more comprehensive view of the role of NK cells in innate immunity is now available.
AB - Natural killer (NK) cells play a key role in innate host defense against viruses. Significant progress has been made in understanding the specific response of NK cells during viral infections by the recent identification of an NK cell receptor involved in in vivo resistance, and its ligand. New insight has also been provided in NK cell cytokine and chemokine responses, highlighting the complexity of regulatory pathways. Taken together, a more comprehensive view of the role of NK cells in innate immunity is now available.
UR - http://www.scopus.com/inward/record.url?scp=0037290831&partnerID=8YFLogxK
U2 - 10.1016/S095279150200002X
DO - 10.1016/S095279150200002X
M3 - Review article
C2 - 12495732
AN - SCOPUS:0037290831
SN - 0952-7915
VL - 15
SP - 45
EP - 51
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -