Autoimmune diseases are often characterized as clinical syndromes caused by the inappropriate activation of T or B cells resulting in systemic or organ-specific damage. However, studies support a role for the innate immune system, and in particular natural killer (NK) cells, in stimulating or suppressing autoimmunity. This review focuses on recent research elucidating a potential immunoregulatory role for NK cells in modulating T and B cell-mediated autoimmunity.

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalArthritis Research and Therapy
Issue number1
StatePublished - Feb 1 2004


  • Autoimmunity
  • Immunoregulation
  • Natural killer cells


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