TY - JOUR
T1 - Natural killer cell receptors
AU - Yokoyama, Wayne M.
N1 - Funding Information:
I thank Andrew Brooks, Sigbjorn F0ssum, Lewis Lanier, Miguel L6pez-Botet, Jay Ryan, and Jon Vaage for sharing pre-publication manuscripts and I am grateful to Hamish Smith for critical review of the manuscript. Work in the author's laboratory is supported by grants from the National Institutes of Health and the Barnes-Jewish Research Foundation. WMY is an investigator of the Howard Hughes Medical Institute.
PY - 1998/6
Y1 - 1998/6
N2 - In killing of cellular targets, natural killer cells employ receptors that activate them and receptors specific for MHC class I that inhibit their activation. Progress in understanding the inhibitory receptors has been rapid, and indications are that they fall into two distinct structural types that appear to utilize the same inhibitory signaling cascade; meanwhile, components of the activation cascade are being elucidated, permitting us to integrate the pathways involved.
AB - In killing of cellular targets, natural killer cells employ receptors that activate them and receptors specific for MHC class I that inhibit their activation. Progress in understanding the inhibitory receptors has been rapid, and indications are that they fall into two distinct structural types that appear to utilize the same inhibitory signaling cascade; meanwhile, components of the activation cascade are being elucidated, permitting us to integrate the pathways involved.
UR - https://www.scopus.com/pages/publications/0031860633
U2 - 10.1016/S0952-7915(98)80168-4
DO - 10.1016/S0952-7915(98)80168-4
M3 - Article
C2 - 9638366
AN - SCOPUS:0031860633
SN - 0952-7915
VL - 10
SP - 298
EP - 305
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 3
ER -