TY - JOUR
T1 - Natural killer cell receptors
AU - Yokoyama, Wayne M.
N1 - Funding Information:
I thank Karel Bezouska, Ten Feizi, and John Ortaldo for communicating their results before publication, David Margulies for helpful discussions, and the members of my laboratory for their commitment to understanding NK cell recognition. Studies in my laboratory are also supported by NIH grants AI33903 and A134385.
PY - 1995/2
Y1 - 1995/2
N2 - In the past year, significant strides have been made in understanding natural killing, the process whereby natural killer cells lyse target cells. Recognition of susceptible targets and activation now appear to be mediated by a natural killer cell receptor that binds carbohydrate determinants on target cells and initiates target lysis. Conversely, receptors have been identified that bind MHC class I molecules on targets that inhibit natural killer cell activation. These findings provide the basis for understanding the molecular processes in the initial steps of natural killing.
AB - In the past year, significant strides have been made in understanding natural killing, the process whereby natural killer cells lyse target cells. Recognition of susceptible targets and activation now appear to be mediated by a natural killer cell receptor that binds carbohydrate determinants on target cells and initiates target lysis. Conversely, receptors have been identified that bind MHC class I molecules on targets that inhibit natural killer cell activation. These findings provide the basis for understanding the molecular processes in the initial steps of natural killing.
UR - https://www.scopus.com/pages/publications/0028951866
U2 - 10.1016/0952-7915(95)80036-0
DO - 10.1016/0952-7915(95)80036-0
M3 - Article
C2 - 7772274
AN - SCOPUS:0028951866
SN - 0952-7915
VL - 7
SP - 110
EP - 120
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -