Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia

Zhifu Xiang; Varinder Kaur; Ibrahim K. Aburiziq; Paulette Mehta; Peter Emanuel; Steven A. Schichman

doi:10.1002/ccr3.110

Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia

Zhifu Xiang, Varinder Kaur, Ibrahim K. Aburiziq, Paulette Mehta, Peter Emanuel, Steven A. Schichman

Research output: Contribution to journal › Article › peer-review

Abstract

Gene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hematologic malignancies, and to identify the potential targets for therapy.

Original language	English
Pages (from-to)	265-270
Number of pages	6
Journal	Clinical Case Reports
Volume	2
Issue number	6
DOIs	https://doi.org/10.1002/ccr3.110
State	Published - Dec 2014

Keywords

Acute myeloid leukemia
chronic myelomonocytic leukemia
clonality
gene sequencing
genetic abnormality

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10.1002/ccr3.110

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title = "Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia",

abstract = "Gene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hematologic malignancies, and to identify the potential targets for therapy.",

keywords = "Acute myeloid leukemia, chronic myelomonocytic leukemia, clonality, gene sequencing, genetic abnormality",

author = "Zhifu Xiang and Varinder Kaur and Aburiziq, {Ibrahim K.} and Paulette Mehta and Peter Emanuel and Schichman, {Steven A.}",

note = "Publisher Copyright: {\textcopyright} 2014 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.",

year = "2014",

month = dec,

doi = "10.1002/ccr3.110",

language = "English",

volume = "2",

pages = "265--270",

journal = "Clinical Case Reports",

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}

Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia. / Xiang, Zhifu; Kaur, Varinder; Aburiziq, Ibrahim K. et al.
In: Clinical Case Reports, Vol. 2, No. 6, 12.2014, p. 265-270.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Natural history of chronic myelomonocytic leukemia

T2 - gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia

AU - Xiang, Zhifu

AU - Kaur, Varinder

AU - Aburiziq, Ibrahim K.

AU - Mehta, Paulette

AU - Emanuel, Peter

AU - Schichman, Steven A.

PY - 2014/12

Y1 - 2014/12

N2 - Gene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hematologic malignancies, and to identify the potential targets for therapy.

AB - Gene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hematologic malignancies, and to identify the potential targets for therapy.

KW - Acute myeloid leukemia

KW - chronic myelomonocytic leukemia

KW - clonality

KW - gene sequencing

KW - genetic abnormality

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U2 - 10.1002/ccr3.110

DO - 10.1002/ccr3.110

M3 - Article

C2 - 25548628

AN - SCOPUS:85052572473

SN - 2050-0904

VL - 2

SP - 265

EP - 270

JO - Clinical Case Reports

JF - Clinical Case Reports

IS - 6

ER -

Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia

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