Natural history of adenoviral conjunctivitis in a US-based population: Viral load, signs, and symptoms

Jennifer S. Harthan, Tammy Than, Ellen Shorter, Andrew T.E. Hartwick, Christina E. Morettin, Julia B. Huecker, Spencer D. Johnson, Mary K. Migneco, Meredith Whiteside, Christian K. Olson, Christopher S. Alferez, Tavé van Zyl, Mae O. Gordon

Research output: Contribution to journalArticlepeer-review


Purpose: To report the clinical signs, symptoms, and viral clearance in individuals in the United States with adenoviral conjunctivitis (Ad-Cs). Methods: Individuals ≥ 18 years presenting within 4 days of symptoms of Ad-Cs who met eligibility criteria and tested positive with both point-of-care immunoassay antigen and quantitative polymerase chain reaction (qPCR) testing were enrolled. Patient-reported symptoms, clinician-graded signs, and qPCR viral titers were collected at baseline, days 1–2, 4 (days 3–5), 7 (days 6–10), 14 (days 11–17) and 21 (days 18–21). Results: There was no detectable viral titers by the day 14 visit in 6/8 patients. By day 21, there was no detectable viral titers in the 7 participants who completed the visit; however, signs and symptoms persisted including: blurry vision (5/7), discomfort (2/7) or redness (1/7). Masked clinicians also noted conjunctival redness (4/7), follicular conjunctivitis (4/7) and bulbar edema (3/7). Conclusion: Many patient-reported symptoms and clinical signs persist after viral titers are no longer detectable by qPCR. Using clinical signs and symptoms to determine quarantine duration may result in patients being furloughed longer than the time that the patient is infectious.

Original languageEnglish
Article number102110
JournalContact Lens and Anterior Eye
Issue number2
StatePublished - Apr 2024


  • Adenovirus
  • Conjunctivitis
  • Natural history


Dive into the research topics of 'Natural history of adenoviral conjunctivitis in a US-based population: Viral load, signs, and symptoms'. Together they form a unique fingerprint.

Cite this