TY - JOUR
T1 - National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards
AU - Hachinski, Vladimir
AU - Iadecola, Costantino
AU - Petersen, Ron C.
AU - Breteler, Monique M.
AU - Nyenhuis, David L.
AU - Black, Sandra E.
AU - Powers, William J.
AU - DeCarli, Charles
AU - Merino, Jose G.
AU - Kalaria, Raj N.
AU - Vinters, Harry V.
AU - Holtzman, David M.
AU - Rosenberg, Gary A.
AU - Dichgans, Martin
AU - Marler, John R.
AU - Leblanc, Gabrielle G.
PY - 2006/9
Y1 - 2006/9
N2 - BACKGROUND AND PURPOSE - One in 3 individuals will experience a stroke, dementia or both. Moreover, twice as many individuals will have cognitive impairment short of dementia as either stroke or dementia. The commonly used stroke scales do not measure cognition, while dementia criteria focus on the late stages of cognitive impairment, and are heavily biased toward the diagnosis of Alzheimer disease. No commonly agreed standards exist for identifying and describing individuals with cognitive impairment, particularly in the early stages, and especially with cognitive impairment related to vascular factors, or vascular cognitive impairment. METHODS - The National Institute for Neurological Disorders and Stroke (NINDS) and the Canadian Stroke Network (CSN) convened researchers in clinical diagnosis, epidemiology, neuropsychology, brain imaging, neuropathology, experimental models, biomarkers, genetics, and clinical trials to recommend minimum, common, clinical and research standards for the description and study of vascular cognitive impairment. RESULTS - The results of these discussions are reported herein. CONCLUSIONS - The development of common standards represents a first step in a process of use, validation and refinement. Using the same standards will help identify individuals in the early stages of cognitive impairment, will make studies comparable, and by integrating knowledge, will accelerate the pace of progress.
AB - BACKGROUND AND PURPOSE - One in 3 individuals will experience a stroke, dementia or both. Moreover, twice as many individuals will have cognitive impairment short of dementia as either stroke or dementia. The commonly used stroke scales do not measure cognition, while dementia criteria focus on the late stages of cognitive impairment, and are heavily biased toward the diagnosis of Alzheimer disease. No commonly agreed standards exist for identifying and describing individuals with cognitive impairment, particularly in the early stages, and especially with cognitive impairment related to vascular factors, or vascular cognitive impairment. METHODS - The National Institute for Neurological Disorders and Stroke (NINDS) and the Canadian Stroke Network (CSN) convened researchers in clinical diagnosis, epidemiology, neuropsychology, brain imaging, neuropathology, experimental models, biomarkers, genetics, and clinical trials to recommend minimum, common, clinical and research standards for the description and study of vascular cognitive impairment. RESULTS - The results of these discussions are reported herein. CONCLUSIONS - The development of common standards represents a first step in a process of use, validation and refinement. Using the same standards will help identify individuals in the early stages of cognitive impairment, will make studies comparable, and by integrating knowledge, will accelerate the pace of progress.
KW - Binswangers disease
KW - CADASIL
KW - Cerebral infarction
KW - Cerebrovascular disorders
KW - Dementia
KW - Genetics
KW - Ischemia
KW - Lacunar infarction
KW - Leukoaraiosis
KW - Neuropsychology
KW - Stroke
KW - Syndrome
KW - Vascular dementia
UR - http://www.scopus.com/inward/record.url?scp=33748352752&partnerID=8YFLogxK
U2 - 10.1161/01.STR.0000237236.88823.47
DO - 10.1161/01.STR.0000237236.88823.47
M3 - Article
C2 - 16917086
AN - SCOPUS:33748352752
SN - 0039-2499
VL - 37
SP - 2220
EP - 2241
JO - Stroke
JF - Stroke
IS - 9
ER -