Nasal and paranasal sinus mucosal melanoma: Long-term survival outcomes and prognostic factors

Nicholas B. Abt, Lauren E. Miller, Tara E. Mokhtari, Derrick T. Lin, Jeremy D. Richmon, Daniel G. Deschler, Mark A. Varvares, Sidharth V. Puram

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Objective: To determine prognostic factors and survival patterns for different treatment modalities for nasal cavity (NC) and paranasal sinus (PS) mucosal melanoma (MM). Methods: Patients from 1973 to 2013 were analyzed using the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier method and multivariable cox proportional hazard modeling were used for survival analyses. Results: Of 928 cases of mucosal melanoma (NC = 632, PS = 302), increasing age (Hazard Ratio [HR]:1.05/year, p < 0.001), T4 tumors (HR: 1.81, p = 0.02), N1 status (HR: 6.61, p < 0.001), and PS disease (HR: 1.50, p < 0.001) were associated with worse survival. Median survival length was lower for PS versus NC (16 versus 26 months, p < 0.001). Surgery and surgery + radiation therapy (RT) improved survival over non-treatment or RT alone (p < 0.001). Adding RT to surgery did not yield a survival difference compared with surgery alone (p = 0.43). Five-year survival rates for surgery and surgery + RT were similar, at 27.7% and 25.1% (p = 0.43). Conclusion: Surgery increased survival significantly over RT alone. RT following surgical resection did not improve survival.

Original languageEnglish
Article number103070
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume42
Issue number6
DOIs
StatePublished - Nov 1 2021

Keywords

  • Cancer
  • Melanoma
  • Mucosal
  • Nasal cavity
  • Neoplasm
  • Paranasal sinus
  • Survival
  • Tumor

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