TY - JOUR
T1 - Narrowing the spectrum
T2 - The new frontier of precision antimicrobials
AU - Paharik, Alexandra E.
AU - Schreiber, Henry L.
AU - Spaulding, Caitlin N.
AU - Dodson, Karen W.
AU - Hultgren, Scott J.
N1 - Funding Information:
This work is supported by grants from the NIH: RO1DK051406, R01AI048689, and P50DK064540. CNS was supported at Washington University School of Medicine by 1F31DK107057.
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/14
Y1 - 2017/12/14
N2 - Antibiotics have become the standard of care for bacterial infections. However, rising rates of antibiotic-resistant infections are outpacing the development of new antimicrobials. Broad-spectrum antibiotics also harm beneficial microbial communities inhabiting humans. To combat antibiotic resistance and protect these communities, new precision antimicrobials must be engineered to target specific pathogens.
AB - Antibiotics have become the standard of care for bacterial infections. However, rising rates of antibiotic-resistant infections are outpacing the development of new antimicrobials. Broad-spectrum antibiotics also harm beneficial microbial communities inhabiting humans. To combat antibiotic resistance and protect these communities, new precision antimicrobials must be engineered to target specific pathogens.
UR - http://www.scopus.com/inward/record.url?scp=85041083926&partnerID=8YFLogxK
U2 - 10.1186/s13073-017-0504-3
DO - 10.1186/s13073-017-0504-3
M3 - Comment/debate
C2 - 29241446
AN - SCOPUS:85041083926
SN - 1756-994X
VL - 9
JO - Genome Medicine
JF - Genome Medicine
IS - 1
M1 - 110
ER -