Nanotherapy Targeting NF-kB Attenuates Acute Pain After Joint Injury

Huimin Yan; Xin Duan; Kelsey H. Collins; Luke E. Springer; Farshid Guilak; Samuel A. Wickline; M. Farooq Rai; Hua Pan; Christine T.N. Pham

doi:10.33218/prnano2(1).181129.1

Nanotherapy Targeting NF-kB Attenuates Acute Pain After Joint Injury

Huimin Yan, Xin Duan, Kelsey H. Collins, Luke E. Springer, Farshid Guilak, Samuel A. Wickline, M. Farooq Rai, Hua Pan, Christine T.N. Pham

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Inflammation after joint injury leads to responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-kB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis in vivo. Herein, we demonstrate that the suppression of NF-kB p65 expression also significantly mitigates the acute pain sensitivity induced by mechanical injury to the joint. These results suggest that early intervention with anti-NF-KB nanotherapy mitigates both structural and pain-related outcomes, which in turn may impact the progr ession of post-traumatic osteoarthr itis.

Original language	English
Pages (from-to)	245-248
Number of pages	4
Journal	Precision Nanomedicine
Volume	2
Issue number	1
DOIs	https://doi.org/10.33218/prnano2(1).181129.1
State	Published - 2019

Keywords

inflammation
joint injury
nanomedicine
nf-kappab
p65
pain

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title = "Nanotherapy Targeting NF-kB Attenuates Acute Pain After Joint Injury",

abstract = "Inflammation after joint injury leads to responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-kB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis in vivo. Herein, we demonstrate that the suppression of NF-kB p65 expression also significantly mitigates the acute pain sensitivity induced by mechanical injury to the joint. These results suggest that early intervention with anti-NF-KB nanotherapy mitigates both structural and pain-related outcomes, which in turn may impact the progr ession of post-traumatic osteoarthr itis.",

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AU - Yan, Huimin

AU - Duan, Xin

AU - Collins, Kelsey H.

AU - Springer, Luke E.

AU - Guilak, Farshid

AU - Wickline, Samuel A.

AU - Farooq Rai, M.

AU - Pan, Hua

AU - Pham, Christine T.N.

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AB - Inflammation after joint injury leads to responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-kB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis in vivo. Herein, we demonstrate that the suppression of NF-kB p65 expression also significantly mitigates the acute pain sensitivity induced by mechanical injury to the joint. These results suggest that early intervention with anti-NF-KB nanotherapy mitigates both structural and pain-related outcomes, which in turn may impact the progr ession of post-traumatic osteoarthr itis.

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Nanotherapy Targeting NF-kB Attenuates Acute Pain After Joint Injury

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