Nanotechnology Strategies to Advance Outcomes in Clinical Cancer Care

Christopher M. Hartshorn, Michelle S. Bradbury, Gregory M. Lanza, Andre E. Nel, Jianghong Rao, Andrew Z. Wang, Ulrich B. Wiesner, Lily Yang, Piotr Grodzinski

Research output: Contribution to journalReview article

77 Scopus citations

Abstract

Ongoing research into the application of nanotechnology for cancer treatment and diagnosis has demonstrated its advantages within contemporary oncology as well as its intrinsic limitations. The National Cancer Institute publishes the Cancer Nanotechnology Plan every 5 years since 2005. The most recent iteration helped codify the ongoing basic and translational efforts of the field and displayed its breadth with several evolving areas. From merely a technological perspective, this field has seen tremendous growth and success. However, an incomplete understanding of human cancer biology persists relative to the application of nanoscale materials within contemporary oncology. As such, this review presents several evolving areas in cancer nanotechnology in order to identify key clinical and biological challenges that need to be addressed to improve patient outcomes. From this clinical perspective, a sampling of the nano-enabled solutions attempting to overcome barriers faced by traditional therapeutics and diagnostics in the clinical setting are discussed. Finally, a strategic outlook of the future is discussed to highlight the need for next-generation cancer nanotechnology tools designed to address critical gaps in clinical cancer care.

Original languageEnglish
Pages (from-to)24-43
Number of pages20
JournalACS nano
Volume12
Issue number1
DOIs
StatePublished - Jan 23 2018

Keywords

  • Cancer Nanotechnology Plan
  • National Cancer Institute
  • alliance
  • biological barriers
  • cancer
  • image-guided surgery
  • immunotherapy
  • metastasis
  • nanotechnology
  • oncology
  • radiotherapy

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  • Cite this

    Hartshorn, C. M., Bradbury, M. S., Lanza, G. M., Nel, A. E., Rao, J., Wang, A. Z., Wiesner, U. B., Yang, L., & Grodzinski, P. (2018). Nanotechnology Strategies to Advance Outcomes in Clinical Cancer Care. ACS nano, 12(1), 24-43. https://doi.org/10.1021/acsnano.7b05108