Nanosensing applications of in2O3 nanowires and carbon nanotubes

Chongwu Zhou; Chao Li; Marco Curreli; Henry Lin; Fumiaki N. Ishikawa; Ram Datar; Richard J. Cote; Mark E. Thompson

doi:10.1117/12.631077

Nanosensing applications of in₂O₃ nanowires and carbon nanotubes

Chongwu Zhou, Chao Li, Marco Curreli, Henry Lin, Fumiaki N. Ishikawa, Ram Datar, Richard J. Cote, Mark E. Thompson

Research output: Contribution to journal › Conference article › peer-review

Abstract

We report complementary detection of prostate-specific antigen (PSA) using n-type In₂O₃ nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In₂O₃ NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In₂O₃ NW and SWNT devices after the binding of PSA. Real time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.

Original language	English
Article number	60080F
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	6008
DOIs	https://doi.org/10.1117/12.631077
State	Published - Dec 1 2005
Event	Nanosensing: Materials and Devices II - Boston, MA, United States Duration: Oct 23 2005 → Oct 26 2005

Keywords

Biosensor
Carbon nanotubes
InO nanowires
PSA detection

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10.1117/12.631077

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title = "Nanosensing applications of in2O3 nanowires and carbon nanotubes",

abstract = "We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.",

keywords = "Biosensor, Carbon nanotubes, InO nanowires, PSA detection",

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year = "2005",

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T1 - Nanosensing applications of in2O3 nanowires and carbon nanotubes

AU - Zhou, Chongwu

AU - Li, Chao

AU - Curreli, Marco

AU - Lin, Henry

AU - Ishikawa, Fumiaki N.

AU - Datar, Ram

AU - Cote, Richard J.

AU - Thompson, Mark E.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.

AB - We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.

KW - Biosensor

KW - Carbon nanotubes

KW - InO nanowires

KW - PSA detection

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DO - 10.1117/12.631077

M3 - Conference article

AN - SCOPUS:33644681128

SN - 0277-786X

VL - 6008

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

M1 - 60080F

T2 - Nanosensing: Materials and Devices II

Y2 - 23 October 2005 through 26 October 2005

ER -

Nanosensing applications of in₂O₃ nanowires and carbon nanotubes

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Keywords

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