We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.
|Journal||Proceedings of SPIE - The International Society for Optical Engineering|
|State||Published - Dec 1 2005|
|Event||Nanosensing: Materials and Devices II - Boston, MA, United States|
Duration: Oct 23 2005 → Oct 26 2005
- Carbon nanotubes
- InO nanowires
- PSA detection