Nanoporous membranes with mixed nanoclusters for Raman-based label-free monitoring of peroxide compounds

Sehoon Chang, Hyunhyub Ko, Srikanth Singamaneni, Ray Gunawidjaja, Vladimir V. Tsukruk

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Monitoring trace amounts of peroxide-based molecules is challenging because of the lack of common optical signatures (fluorescence or absorption in UV-vis range) or chemical functionality easily detectable with common routines. To overcome this issue, we suggest a photo-chemical decomposition approach followed by the analysis of chemical fragments by a fast, sensitive, and reliable Raman spectroscopic method. To facilitate this approach, we employed a novel design of surface-enhanced Raman scattering (SERS)-active nanoporous substrate based on porous alumina membranes decorated with mixed nano-clusters composed of gold nanorods and nanoparticles. The detectable amount of HMTD below 2 pg demonstrated here is about 3 orders of magnitude lower than the current limit of detection. We suggest that laser-induced photo-catalytic decomposition onto nanoparticle clusters is critical for achieving label-free detection of unstable and nonresonant organic molecules.

Original languageEnglish
Pages (from-to)5740-5748
Number of pages9
JournalAnalytical Chemistry
Volume81
Issue number14
DOIs
StatePublished - Jul 15 2009

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