TY - JOUR
T1 - Nanoporous membranes with mixed nanoclusters for Raman-based label-free monitoring of peroxide compounds
AU - Chang, Sehoon
AU - Ko, Hyunhyub
AU - Singamaneni, Srikanth
AU - Gunawidjaja, Ray
AU - Tsukruk, Vladimir V.
PY - 2009/7/15
Y1 - 2009/7/15
N2 - Monitoring trace amounts of peroxide-based molecules is challenging because of the lack of common optical signatures (fluorescence or absorption in UV-vis range) or chemical functionality easily detectable with common routines. To overcome this issue, we suggest a photo-chemical decomposition approach followed by the analysis of chemical fragments by a fast, sensitive, and reliable Raman spectroscopic method. To facilitate this approach, we employed a novel design of surface-enhanced Raman scattering (SERS)-active nanoporous substrate based on porous alumina membranes decorated with mixed nano-clusters composed of gold nanorods and nanoparticles. The detectable amount of HMTD below 2 pg demonstrated here is about 3 orders of magnitude lower than the current limit of detection. We suggest that laser-induced photo-catalytic decomposition onto nanoparticle clusters is critical for achieving label-free detection of unstable and nonresonant organic molecules.
AB - Monitoring trace amounts of peroxide-based molecules is challenging because of the lack of common optical signatures (fluorescence or absorption in UV-vis range) or chemical functionality easily detectable with common routines. To overcome this issue, we suggest a photo-chemical decomposition approach followed by the analysis of chemical fragments by a fast, sensitive, and reliable Raman spectroscopic method. To facilitate this approach, we employed a novel design of surface-enhanced Raman scattering (SERS)-active nanoporous substrate based on porous alumina membranes decorated with mixed nano-clusters composed of gold nanorods and nanoparticles. The detectable amount of HMTD below 2 pg demonstrated here is about 3 orders of magnitude lower than the current limit of detection. We suggest that laser-induced photo-catalytic decomposition onto nanoparticle clusters is critical for achieving label-free detection of unstable and nonresonant organic molecules.
UR - http://www.scopus.com/inward/record.url?scp=67650744856&partnerID=8YFLogxK
U2 - 10.1021/ac900537d
DO - 10.1021/ac900537d
M3 - Article
C2 - 19518140
AN - SCOPUS:67650744856
SN - 0003-2700
VL - 81
SP - 5740
EP - 5748
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 14
ER -