TY - JOUR
T1 - Nanoparticles labeled with positron emitting nuclides
T2 - Advantages, methods, and applications
AU - Liu, Yongjian
AU - Welch, Michael J.
PY - 2012/4/18
Y1 - 2012/4/18
N2 - (Graph Presented) Over the past decade, positron emitter labeled nanoparticles have been widely used in and substantially improved for a range of diagnostic biomedical research. However, given growing interest in personalized medicine and translational research, a major challenge in the field will be to develop disease-specific nanoprobes with facile and robust radiolabeling strategies and that provide imaging stability, enhanced sensitivity for disease early stage detection, optimized in vivo pharmacokinetics for reduced nonspecific organ uptake, and improved targeting for elevated efficacy. This review briefly summarizes the major applications of nanoparticles labeled with positron emitters for cardiovascular imaging, lung diagnosis, and tumor theranostics.
AB - (Graph Presented) Over the past decade, positron emitter labeled nanoparticles have been widely used in and substantially improved for a range of diagnostic biomedical research. However, given growing interest in personalized medicine and translational research, a major challenge in the field will be to develop disease-specific nanoprobes with facile and robust radiolabeling strategies and that provide imaging stability, enhanced sensitivity for disease early stage detection, optimized in vivo pharmacokinetics for reduced nonspecific organ uptake, and improved targeting for elevated efficacy. This review briefly summarizes the major applications of nanoparticles labeled with positron emitters for cardiovascular imaging, lung diagnosis, and tumor theranostics.
UR - http://www.scopus.com/inward/record.url?scp=84859967416&partnerID=8YFLogxK
U2 - 10.1021/bc200264c
DO - 10.1021/bc200264c
M3 - Review article
C2 - 22242601
AN - SCOPUS:84859967416
VL - 23
SP - 671
EP - 682
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
SN - 1043-1802
IS - 4
ER -