Nanoparticles labeled with positron emitting nuclides: Advantages, methods, and applications

Yongjian Liu, Michael J. Welch

Research output: Contribution to journalReview article

88 Scopus citations

Abstract

(Graph Presented) Over the past decade, positron emitter labeled nanoparticles have been widely used in and substantially improved for a range of diagnostic biomedical research. However, given growing interest in personalized medicine and translational research, a major challenge in the field will be to develop disease-specific nanoprobes with facile and robust radiolabeling strategies and that provide imaging stability, enhanced sensitivity for disease early stage detection, optimized in vivo pharmacokinetics for reduced nonspecific organ uptake, and improved targeting for elevated efficacy. This review briefly summarizes the major applications of nanoparticles labeled with positron emitters for cardiovascular imaging, lung diagnosis, and tumor theranostics.

Original languageEnglish
Pages (from-to)671-682
Number of pages12
JournalBioconjugate Chemistry
Volume23
Issue number4
DOIs
StatePublished - Apr 18 2012

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