Nanoparticles for Bioimaging: Analytical Characterization and Measurements

Rapid development of nanoparticles for biomedical applications has, to a large extent, been based on a solid analytical foundation built in the previous decades. Such widespread methods are transmission electron microscopy (TEM), scanning electron microscopy (SEM), and inductively coupled plasma mass spectrometry (ICP-MS). A variety of elemental analysis methods are used to both determine the presence of an element in a sample and quantify how much of said element is present. As material properties at the nanoscale often differ from properties at micro-and macroscales, great attention is often paid to particle sizing analysis. One of the most commonly used surface analysis tools is scanning probe microscopy (SPM). Radioactivity measurement involves detection of "radioactive decay" of the radionuclide. A magnetic resonance imaging (MRI) system consists of a wide variety of components working together to form the desired images.