Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing

Alastair W. Wark, Jin Lee Hye, Abraham J. Qavi, Robert M. Corn

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.

Original languageEnglish
Pages (from-to)6697-6701
Number of pages5
JournalAnalytical Chemistry
Issue number17
StatePublished - Sep 1 2007


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