Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing

Alastair W. Wark; Jin Lee Hye; Abraham J. Qavi; Robert M. Corn

doi:10.1021/ac071062b

Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing

Alastair W. Wark, Jin Lee Hye, Abraham J. Qavi, Robert M. Corn

Division of Laboratory and Genomic Medicine

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.

Original language	English
Pages (from-to)	6697-6701
Number of pages	5
Journal	Analytical Chemistry
Volume	79
Issue number	17
DOIs	https://doi.org/10.1021/ac071062b
State	Published - Sep 1 2007

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title = "Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing",

abstract = "Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.",

author = "Wark, {Alastair W.} and Hye, {Jin Lee} and Qavi, {Abraham J.} and Corn, {Robert M.}",

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AU - Wark, Alastair W.

AU - Hye, Jin Lee

AU - Qavi, Abraham J.

AU - Corn, Robert M.

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.

AB - Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.

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M3 - Article

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JO - Analytical Chemistry

JF - Analytical Chemistry

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Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing

Abstract

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