Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing

Alastair W. Wark, Jin Lee Hye, Abraham J. Qavi, Robert M. Corn

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.

Original languageEnglish
Pages (from-to)6697-6701
Number of pages5
JournalAnalytical Chemistry
Volume79
Issue number17
DOIs
StatePublished - Sep 1 2007

Fingerprint

Dive into the research topics of 'Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing'. Together they form a unique fingerprint.

Cite this