Nanomedicine strategies for molecular targets with MRI and optical imaging

Dipanjan Pan, Shelton D. Caruthers, Junjie Chen, Patrick M. Winter, Angana Senpan, Anne H. Schmieder, Samuel A. Wickline, Gregory M. Lanza

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations


The science of 'theranostics plays a crucial role in personalized medicine, which represents the future of patient management. Over the last decade an increasing research effort has focused on the development of nanoparticle-based molecular-imaging and drug-delivery approaches, emerging as a multidisciplinary field that shows promise in understanding the components, processes, dynamics and therapies of a disease at a molecular level. The potential of nanometer-sized agents for early detection, diagnosis and personalized treatment of diseases is extraordinary. They have found applications in almost all clinically relevant biomedical imaging modality. In this review, a number of these approaches will be presented with a particular emphasis on MRI and optical imaging-based techniques. We have discussed both established molecular-imaging approaches and recently developed innovative strategies, highlighting the seminal studies and a number of successful examples of theranostic nanomedicine, especially in the areas of cardiovascular and cancer therapy.

Original languageEnglish
Pages (from-to)471-490
Number of pages20
JournalFuture medicinal chemistry
Issue number3
StatePublished - Mar 2010


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