@inproceedings{2ef54c34cc67493385152315993f9abd,
title = "Nanomechanical sensor array for detection of biomolecular bindings-toward a label-free clinical assay for serum tumor markers",
abstract = "An array of cantilever sensors, that is capable of rapidly screening human blood samples for multiple serum tumor markers and interrogating 100 different biomolecular interactions was discussed. It was found that biomolecular interactions take place in individual microfluidic wells containing 4 to 12 cantilever sensors. The physical and chemical effects such as solvent interactions, osmotic pressure and strain energy were studied that were responsible for cantilever deflection using the immobilization of thiolated DNA on gold-coated cantilever and hybridization as a model system. The results show that the cantilever arrays were capable of multiplexed specific antibody-antigen binding detection.",
author = "Min Yue and Henry Lin and Ram Datar and Thomas Thundat and Cote, {Richard J.} and Stachowiak, {Jeanne C.} and Kenneth Castelino and Karolyn Hansen and Arup Chakraborty and Arun Majumdar",
year = "2004",
month = dec,
day = "1",
language = "English",
isbn = "0791841774",
series = "Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications",
pages = "27--28",
booktitle = "Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications",
note = "null ; Conference date: 22-09-2004 Through 24-09-2004",
}