Nanomechanical sensor array for detection of biomolecular bindings-toward a label-free clinical assay for serum tumor markers

Min Yue; Henry Lin; Ram Datar; Thomas Thundat; Richard J. Cote; Jeanne C. Stachowiak; Kenneth Castelino; Karolyn Hansen; Arup Chakraborty; Arun Majumdar

Nanomechanical sensor array for detection of biomolecular bindings-toward a label-free clinical assay for serum tumor markers

Min Yue, Henry Lin, Ram Datar, Thomas Thundat, Richard J. Cote, Jeanne C. Stachowiak, Kenneth Castelino, Karolyn Hansen, Arup Chakraborty, Arun Majumdar

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

An array of cantilever sensors, that is capable of rapidly screening human blood samples for multiple serum tumor markers and interrogating 100 different biomolecular interactions was discussed. It was found that biomolecular interactions take place in individual microfluidic wells containing 4 to 12 cantilever sensors. The physical and chemical effects such as solvent interactions, osmotic pressure and strain energy were studied that were responsible for cantilever deflection using the immobilization of thiolated DNA on gold-coated cantilever and hybridization as a model system. The results show that the cantilever arrays were capable of multiplexed specific antibody-antigen binding detection.

Original language	English
Title of host publication	Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications
Pages	27-28
Number of pages	2
State	Published - Dec 1 2004
Event	3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications - Pasadena, CA, United States Duration: Sep 22 2004 → Sep 24 2004

Publication series

Name	Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications

Conference

Conference	3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications
Country/Territory	United States
City	Pasadena, CA
Period	09/22/04 → 09/24/04

Cite this

Yue, M., Lin, H., Datar, R., Thundat, T., Cote, R. J., Stachowiak, J. C., Castelino, K., Hansen, K., Chakraborty, A., & Majumdar, A. (2004). Nanomechanical sensor array for detection of biomolecular bindings-toward a label-free clinical assay for serum tumor markers. In Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications (pp. 27-28). Article NANO2004-46034 (Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications).

Yue, Min ; Lin, Henry ; Datar, Ram et al. / Nanomechanical sensor array for detection of biomolecular bindings-toward a label-free clinical assay for serum tumor markers. Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications. 2004. pp. 27-28 (Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications).

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title = "Nanomechanical sensor array for detection of biomolecular bindings-toward a label-free clinical assay for serum tumor markers",

abstract = "An array of cantilever sensors, that is capable of rapidly screening human blood samples for multiple serum tumor markers and interrogating 100 different biomolecular interactions was discussed. It was found that biomolecular interactions take place in individual microfluidic wells containing 4 to 12 cantilever sensors. The physical and chemical effects such as solvent interactions, osmotic pressure and strain energy were studied that were responsible for cantilever deflection using the immobilization of thiolated DNA on gold-coated cantilever and hybridization as a model system. The results show that the cantilever arrays were capable of multiplexed specific antibody-antigen binding detection.",

author = "Min Yue and Henry Lin and Ram Datar and Thomas Thundat and Cote, {Richard J.} and Stachowiak, {Jeanne C.} and Kenneth Castelino and Karolyn Hansen and Arup Chakraborty and Arun Majumdar",

year = "2004",

month = dec,

day = "1",

language = "English",

isbn = "0791841774",

series = "Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications",

pages = "27--28",

booktitle = "Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications",

note = "3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications ; Conference date: 22-09-2004 Through 24-09-2004",

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Yue, M, Lin, H, Datar, R, Thundat, T, Cote, RJ, Stachowiak, JC, Castelino, K, Hansen, K, Chakraborty, A & Majumdar, A 2004, Nanomechanical sensor array for detection of biomolecular bindings-toward a label-free clinical assay for serum tumor markers. in Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications., NANO2004-46034, Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications, pp. 27-28, 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications, Pasadena, CA, United States, 09/22/04.

Nanomechanical sensor array for detection of biomolecular bindings-toward a label-free clinical assay for serum tumor markers. / Yue, Min; Lin, Henry; Datar, Ram et al.
Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications. 2004. p. 27-28 NANO2004-46034 (Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Nanomechanical sensor array for detection of biomolecular bindings-toward a label-free clinical assay for serum tumor markers

AU - Yue, Min

AU - Lin, Henry

AU - Datar, Ram

AU - Thundat, Thomas

AU - Cote, Richard J.

AU - Stachowiak, Jeanne C.

AU - Castelino, Kenneth

AU - Hansen, Karolyn

AU - Chakraborty, Arup

AU - Majumdar, Arun

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N2 - An array of cantilever sensors, that is capable of rapidly screening human blood samples for multiple serum tumor markers and interrogating 100 different biomolecular interactions was discussed. It was found that biomolecular interactions take place in individual microfluidic wells containing 4 to 12 cantilever sensors. The physical and chemical effects such as solvent interactions, osmotic pressure and strain energy were studied that were responsible for cantilever deflection using the immobilization of thiolated DNA on gold-coated cantilever and hybridization as a model system. The results show that the cantilever arrays were capable of multiplexed specific antibody-antigen binding detection.

AB - An array of cantilever sensors, that is capable of rapidly screening human blood samples for multiple serum tumor markers and interrogating 100 different biomolecular interactions was discussed. It was found that biomolecular interactions take place in individual microfluidic wells containing 4 to 12 cantilever sensors. The physical and chemical effects such as solvent interactions, osmotic pressure and strain energy were studied that were responsible for cantilever deflection using the immobilization of thiolated DNA on gold-coated cantilever and hybridization as a model system. The results show that the cantilever arrays were capable of multiplexed specific antibody-antigen binding detection.

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BT - Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications

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Yue M, Lin H, Datar R, Thundat T, Cote RJ, Stachowiak JC et al. Nanomechanical sensor array for detection of biomolecular bindings-toward a label-free clinical assay for serum tumor markers. In Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications. 2004. p. 27-28. NANO2004-46034. (Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications).

Nanomechanical sensor array for detection of biomolecular bindings-toward a label-free clinical assay for serum tumor markers

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