Abstract
We present the development of a new imaging technique for the early diagnosis of hepatocellular carcinoma that utilizes surface-modified gold nanoparticles in combination with X-ray imaging. Tissues labeled with these electron-dense particles show enhanced X-ray scattering over normal tissues, distinguishing cells containing gold nanoparticles from cells without gold in X-ray scatter images. Our results suggest that this novel approach could enable the in vivo detection of tumors as small as a few millimeters in size.
| Original language | English |
|---|---|
| Pages (from-to) | 2678-2683 |
| Number of pages | 6 |
| Journal | Nano Letters |
| Volume | 11 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 13 2011 |
Keywords
- Gold nanoparticles
- X-ray scattering
- early diagnosis
- hepatocellular carcinoma
- layer-by-layer assembly
- spatial harmonic imaging