Nano-scale and micro-scale substrate architectures direct collagen alignment in tendon neo-tissue formation

Christopher L. Gilchrist, David S. Ruch, Dianne Little, Farshid Guilak

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biomaterial scaffolds that present defined microenvironmental cues (e.g., nano-topography) to cells have shown promise for a variety of tissue engineering applications. However, the specific cues best suited for promoting the formation of aligned, fibrous tissues such as tendon are not fully understood. In this study, we utilize a microphotopatterning (μPP) model system to precisely arrange scaffoldmimicking microenvironmental cues and investigate their role in the formation of tendon-like neo-tissues. Our data show that scaffold architectural features at both nano- and micro- length scales may be important parameters for directing tendon-like cell organization and the formation of aligned, fibrillar collagen.

Original languageEnglish
Title of host publicationASME 2013 Summer Bioengineering Conference, SBC 2013
DOIs
StatePublished - Dec 1 2013
Externally publishedYes
EventASME 2013 Summer Bioengineering Conference, SBC 2013 - Sunriver, OR, United States
Duration: Jun 26 2013Jun 29 2013

Publication series

NameASME 2013 Summer Bioengineering Conference, SBC 2013
Volume1 B

Conference

ConferenceASME 2013 Summer Bioengineering Conference, SBC 2013
CountryUnited States
CitySunriver, OR
Period06/26/1306/29/13

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  • Cite this

    Gilchrist, C. L., Ruch, D. S., Little, D., & Guilak, F. (2013). Nano-scale and micro-scale substrate architectures direct collagen alignment in tendon neo-tissue formation. In ASME 2013 Summer Bioengineering Conference, SBC 2013 (ASME 2013 Summer Bioengineering Conference, SBC 2013; Vol. 1 B). https://doi.org/10.1115/SBC2013-14474