TY - GEN
T1 - Nano-scale and micro-scale substrate architectures direct collagen alignment in tendon neo-tissue formation
AU - Gilchrist, Christopher L.
AU - Ruch, David S.
AU - Little, Dianne
AU - Guilak, Farshid
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Biomaterial scaffolds that present defined microenvironmental cues (e.g., nano-topography) to cells have shown promise for a variety of tissue engineering applications. However, the specific cues best suited for promoting the formation of aligned, fibrous tissues such as tendon are not fully understood. In this study, we utilize a microphotopatterning (μPP) model system to precisely arrange scaffoldmimicking microenvironmental cues and investigate their role in the formation of tendon-like neo-tissues. Our data show that scaffold architectural features at both nano- and micro- length scales may be important parameters for directing tendon-like cell organization and the formation of aligned, fibrillar collagen.
AB - Biomaterial scaffolds that present defined microenvironmental cues (e.g., nano-topography) to cells have shown promise for a variety of tissue engineering applications. However, the specific cues best suited for promoting the formation of aligned, fibrous tissues such as tendon are not fully understood. In this study, we utilize a microphotopatterning (μPP) model system to precisely arrange scaffoldmimicking microenvironmental cues and investigate their role in the formation of tendon-like neo-tissues. Our data show that scaffold architectural features at both nano- and micro- length scales may be important parameters for directing tendon-like cell organization and the formation of aligned, fibrillar collagen.
UR - http://www.scopus.com/inward/record.url?scp=84894660435&partnerID=8YFLogxK
U2 - 10.1115/SBC2013-14474
DO - 10.1115/SBC2013-14474
M3 - Conference contribution
AN - SCOPUS:84894660435
SN - 9780791855614
T3 - ASME 2013 Summer Bioengineering Conference, SBC 2013
BT - ASME 2013 Summer Bioengineering Conference, SBC 2013
T2 - ASME 2013 Summer Bioengineering Conference, SBC 2013
Y2 - 26 June 2013 through 29 June 2013
ER -