Nano-CaCO3 as a pH sensitive theranostic platform

Avik Som, Ramesh Raliya, Limei Tian, Kvar Black, Walter Akers, Joseph Ippolito, Srikanth Singamaneni, Pratim Biswas, Samuel Achilefu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Theranostic platforms allow the capability of both diagnostic level imaging and therapy for diseases such as cancer. The decreased pH found in the extracellular environment in cancer is an ideal target for cancer theranostics, because it is both a unique and universal hallmark that distinguishes tumor regions from normal tissue, but also that the decreased pH has been linked to tumor growth and metastasis. We describe herein the development of nano-CaCO3, a novel nanoparticle that can both increase pH in vivo resulting in therapeutic benefit, but also dissolves only at pHs less than 7.4 in vivo, creating a pH sensitivity to the nanoparticle that can be used to detect the more acidic pH ranges in vivo. As a result, nano-CaCO3 is pH sensitive theranostic platform for cancer detection and treatment in vivo.

Original languageEnglish
Title of host publicationCancer Imaging and Therapy, CANCER 2016
PublisherOSA - The Optical Society
ISBN (Print)9781943580101
DOIs
StatePublished - Jul 21 2014
EventCancer Imaging and Therapy, CANCER 2016 - Fort Lauderdale, United States
Duration: Apr 25 2016Apr 28 2016

Publication series

NameOptics InfoBase Conference Papers

Conference

ConferenceCancer Imaging and Therapy, CANCER 2016
CountryUnited States
CityFort Lauderdale
Period04/25/1604/28/16

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  • Cite this

    Som, A., Raliya, R., Tian, L., Black, K., Akers, W., Ippolito, J., Singamaneni, S., Biswas, P., & Achilefu, S. (2014). Nano-CaCO3 as a pH sensitive theranostic platform. In Cancer Imaging and Therapy, CANCER 2016 (Optics InfoBase Conference Papers). OSA - The Optical Society. https://doi.org/10.1364/CANCER.2016.JW4A.4